ZFIN ID: ZDB-GENE-030826-1
Gene Name: baculoviral IAP repeat containing 5a
Gene Symbol: birc5a    Nomenclature History

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Previous Names: survivin 1 (1), survivin (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in several processes, including circulatory system development; positive regulation of angiogenesis; and regulation of apoptotic process. Predicted to localize to cytoplasm; nucleus; and spindle microtubule. Is expressed in axial vasculature; brain; and central nervous system. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5).
Genome Resources: Alliance (1),  Gene:373110 (1),  Ensembl(GRCz11):ENSDARG00000075621 (2)
GENE EXPRESSION
All Expression Data: 10 figures from 9 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi1326Tg Transgenic Insertion Intron 2 Unknown DNA
hi2111Tg Transgenic Insertion Intron 3 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi3018cTg Transgenic Insertion Unknown Unknown DNA
    sa27995 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-birc5a N/A 5
    MO2-birc5a N/A 2
    MO3-birc5a N/A 1
    MO4-birc5a N/A 1
    MO5-birc5a N/A 1
    DISEASE ASSOCIATED WITH birc5a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH birc5a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component cytoplasm (more)
    Molecular Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA birc5a-201 (1)    Ensembl 1471
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-birc5 monoclonal IgG2a Mouse 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM birc5a No data available
    MARKER RELATIONSHIPS
    birc5a Contained in: [BAC] CH73-369D14 (1), DKEYP-92C5 (1)
    birc5a Encodes: [cDNA] MGC:66070 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_194397 (1) 1239 nt
    Genomic GenBank:CR932362 (1) 190415 nt
    Select Tool
    Polypeptide UniProtKB:F1QTF4 (1) 190 aa
    Sequence Information (all 16)
    ORTHOLOGY for birc5a ( Chr: 12 )
    CITATIONS (46)