Gene

kif1b

ID
ZDB-GENE-030820-1
Name
kinesin family member 1B
Symbol
kif1b Nomenclature History
Previous Names
  • unm st43
  • unm_st43
  • wu:fb74c11
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have ATP-dependent microtubule motor activity, plus-end-directed and microtubule binding activity. Involved in several processes, including macrophage differentiation; nervous system development; and neuron projection maintenance. Predicted to localize to several cellular components, including axon; dendrite; and microtubule cytoskeleton. Is expressed in central nervous system; nervous system; neurons; and spinal cord. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2A1; carcinoma (multiple); multiple sclerosis; neuroblastoma; and pheochromocytoma. Orthologous to human KIF1B (kinesin family member 1B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kif1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease type 2A1 Alliance Charcot-Marie-Tooth disease, type 2A1 118210
pheochromocytoma Alliance Pheochromocytoma 171300
{Neuroblastoma, susceptibility to, 1} 256700
Associated With kif1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019821 Kinesin motor domain, conserved site
Domain IPR000253 Forkhead-associated (FHA) domain
Domain IPR001752 Kinesin motor domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR022140 Kinesin-like KIF1-type
Domain IPR022164 Kinesin-like
Domain IPR032405 Kinesin-associated
Family IPR027640 Kinesin-like protein
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length Forkhead-associated (FHA) domain Kinesin-associated Kinesin-like Kinesin-like KIF1-type Kinesin-like protein Kinesin motor domain Kinesin motor domain, conserved site Kinesin motor domain superfamily PH-like domain superfamily Pleckstrin homology domain P-loop containing nucleoside triphosphate hydrolase SMAD/FHA domain superfamily
UniProtKB:F1QJ64 1161
UniProtKB:Q8JIX1 1161
UniProtKB:E9QDE5 1763
UniProtKB:C0LSN9 1770
UniProtKB:F1QBV5 1770
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations