Gene

kif1b

ID
ZDB-GENE-030820-1
Name
kinesin family member 1B
Symbol
kif1b Nomenclature History
Previous Names
  • unm st43
  • unm_st43
  • wu:fb74c11
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have ATP-dependent microtubule motor activity, plus-end-directed and microtubule binding activity. Involved in several processes, including macrophage differentiation; plasma membrane bounded cell projection organization; and posterior lateral line system development. Predicted to localize to several cellular components, including axon; dendrite; and microtubule cytoskeleton. Is expressed in nervous system and neurons. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2A1; carcinoma (multiple); multiple sclerosis; neuroblastoma; and pheochromocytoma. Orthologous to human KIF1B (kinesin family member 1B).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kif1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease type 2A1 Alliance ?Charcot-Marie-Tooth disease, type 2A1 118210
pheochromocytoma Alliance Pheochromocytoma 171300
{Neuroblastoma, susceptibility to, 1} 256700
Associated With kif1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019821 Kinesin motor domain, conserved site
Domain IPR000253 Forkhead-associated (FHA) domain
Domain IPR001752 Kinesin motor domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR022140 Kinesin-like KIF1-type
Domain IPR022164 Kinesin-like
Domain IPR032405 Kinesin-associated
Family IPR027640 Kinesin-like protein
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length Forkhead-associated (FHA) domain Kinesin-associated Kinesin-like Kinesin-like KIF1-type Kinesin-like protein Kinesin motor domain Kinesin motor domain, conserved site Kinesin motor domain superfamily PH-like domain superfamily Pleckstrin homology domain P-loop containing nucleoside triphosphate hydrolase SMAD/FHA domain superfamily
UniProtKB:F1QJ64 1161
UniProtKB:Q8JIX1 1161
UniProtKB:E9QDE5 1763
UniProtKB:C0LSN9 1770
UniProtKB:F1QBV5 1770
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations