ZFIN Gene: kif1b

ZFIN ID: ZDB-GENE-030820-1

ZFIN ID: ZDB-GENE-030820-1

Gene Name:

kinesin family member 1B

Gene Symbol:

kif1b

Sequence Ontology ID :

SO:0000704

Previous Names:

unm st43, unm_st43, wu:fb74c11

Location:

Chr: 23 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have ATP-dependent microtubule motor activity, plus-end-directed and microtubule binding activity. Involved in several processes, including axon extension; neuron projection maintenance; ...

GENE EXPRESSION
All Expression Data:	Fig. 1 from Lyons et al., 2009
Wild-type Stages, Structures:	Pharyngula:Prim-15 (30.0h-36.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	nervous system neuron
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la022637Tg	Transgenic Insertion	Unknown	Unknown	DNA
sa8450	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa16498	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa24361	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37744	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa44007	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa44008	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa44009	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
st43	Point Mutation	Unknown	Unknown		Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

PHENOTYPE

Data:	10 figures from 3 publications
Observed in:	blood island caudal fin axon caudal fin hindbrain compact myelin hindbrain oligodendrocyte macrophage myelin assembly posterior lateral line nerve spinal cord axon spinal cord oligodendrocyte swim bladder thrombocyte whole organism

DISEASE ASSOCIATED WITH kif1b HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
Charcot-Marie-Tooth disease type 2A1	?Charcot-Marie-Tooth disease, type 2A1	118210
pheochromocytoma	Pheochromocytoma	171300
	{Neuroblastoma, susceptibility to, 1}	256700

DISEASE ASSOCIATED WITH kif1b VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	neuron projection maintenance (more)
Cellular Component	axon (more)
Molecular Function	ATP binding (more)

GO Terms (all 21)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000253 (1) InterPro:IPR001752 (1) InterPro:IPR001849 (1) InterPro:IPR008984 (1) InterPro:IPR011993 (1) InterPro:IPR019821 (1) InterPro:IPR022140 (1) InterPro:IPR022164 (1) InterPro:IPR027417 (1) InterPro:IPR027640 (1) InterPro:IPR032405 (1) InterPro:IPR036961 (1)	PROSITE:PS00411 (1) PROSITE:PS50003 (1) PROSITE:PS50067 (1)	Pfam:PF00169 (1) Pfam:PF00225 (1) Pfam:PF00498 (1) Pfam:PF12423 (1) Pfam:PF12473 (1) Pfam:PF16183 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	kif1b-203 (1)	8161	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	kif1b-204 (1)	4012	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM kif1b No data available

MARKER RELATIONSHIPS

kif1bContained in:	[BAC] CH211-129O18 (1) (order this), DKEY-259L18 (1) (order this)
kif1bEncodes:	[EST] 095-d12-2 (1), fb74c11

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_194382 (1)	5477bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX571850 (1)	236136bp	Blast at MegaBLAST
Polypeptide	UniProtKB:C0LSN9 (1)	1770aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:159713 (1)

Sequence Information (all 65)

OTHER kif1b GENE PAGES

Alliance (1)

Gene:369190 (1)

VEGA:OTTDARG00000021340 (1)

Ensembl(GRCz11):ENSDARG00000037020 (2)

ORTHOLOGY for kif1b (Chr: 23)

CITATIONS (32)

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