Gene
kif1b
- ID
- ZDB-GENE-030820-1
- Name
- kinesin family member 1B
- Symbol
- kif1b Nomenclature History
- Previous Names
-
- unm st43
- unm_st43
- wu:fb74c11
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have ATP-dependent microtubule motor activity, plus-end-directed and microtubule binding activity. Involved in several processes, including macrophage differentiation; plasma membrane bounded cell projection organization; and posterior lateral line system development. Predicted to localize to several cellular components, including axon; dendrite; and microtubule cytoskeleton. Is expressed in nervous system and neurons. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2A1; carcinoma (multiple); multiple sclerosis; neuroblastoma; and pheochromocytoma. Orthologous to human KIF1B (kinesin family member 1B).
- Genome Resources
- Note
- None
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease type 2A1 | Alliance | ?Charcot-Marie-Tooth disease, type 2A1 | 118210 |
| pheochromocytoma | Alliance | Pheochromocytoma | 171300 |
| {Neuroblastoma, susceptibility to, 1} | 256700 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR000253 | Forkhead-associated (FHA) domain |
| Domain | IPR001752 | Kinesin motor domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR022140 | Kinesin-like KIF1-type |
| Domain | IPR022164 | Kinesin-like |
| Domain | IPR032405 | Kinesin-associated |
| Family | IPR027640 | Kinesin-like protein |
| Homologous_superfamily | IPR008984 | SMAD/FHA domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Forkhead-associated (FHA) domain | Kinesin-associated | Kinesin-like | Kinesin-like KIF1-type | Kinesin-like protein | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | P-loop containing nucleoside triphosphate hydrolase | SMAD/FHA domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QJ64
|
1161 | ||||||||||||
|
UniProtKB:Q8JIX1
|
1161 | ||||||||||||
|
UniProtKB:E9QDE5
|
1763 | ||||||||||||
|
UniProtKB:C0LSN9
|
1770 | ||||||||||||
|
UniProtKB:F1QBV5
|
1770 |
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl