ZFIN Gene: pdgfrb

ZFIN ID: ZDB-GENE-030805-2

ZFIN ID: ZDB-GENE-030805-2

Gene Name:

platelet-derived growth factor receptor, beta polypeptide

Gene Symbol:

pdgfrb Nomenclature History

Previous Name:

pdgfrb2

Gene Type:

protein_coding_gene

Location:

Unmapped

Description:

Predicted to have ATP binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in animal organ development and vasculature development. Predicted to localize to integral component of membrane. Is expressed in several structures, including blood vessel; floor plate neural tube; gut; hypochord; and somite. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma multiforme; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta).

Genome Resources:

Alliance (1), Gene:559529 (1), Ensembl(GRCz11):ENSDARG00000100897 (1)

GENE EXPRESSION
All Expression Data:	19 figures from 13 publications
Wild-type Stages, Structures:	Segmentation:5-9 somites (11.66h-14.0h) to Larval:Day 4 (96.0h-120.0h)
	anatomical structure brain vasculature pericyte central artery cranial blood vessel cranial neural crest dorsal aorta vascular smooth muscle dorsal aorta dorsal longitudinal anastomotic vessel enteric musculature floor plate neural tube head mesenchyme hypochord intersegmental vessel intestine neural crest cell pericyte pharyngeal arch cranial neural crest cell primary head sinus sclerotome somite ventro-medial region somite border ventral region ventral wall of dorsal aorta anatomical region whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la027549Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa16389	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa22413	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
um148	Small Deletion	Unknown	Frameshift, Premature Stop	TALEN

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-pdgfrb	N/A	4
TALEN1-pdgfrb	um148	1

PHENOTYPE

Data:	3 figures from 3 publications
Observed in:	anatomical structure cerebellar central artery vascular associated smooth muscle cell intersegmental vessel whole organism

DISEASE ASSOCIATED WITH pdgfrb HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
basal ganglia calcification	Alliance	Basal ganglia calcification, idiopathic, 4	615007
infantile myofibromatosis	Alliance	Myofibromatosis, infantile, 1	228550
myeloproliferative disorder with eosinophilia	Alliance	Myeloproliferative disorder with eosinophilia	131440
		Kosaki overgrowth syndrome	616592
		Premature aging syndrome, Penttinen type	601812

DISEASE ASSOCIATED WITH pdgfrb VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	cerebellum vasculature development (more)
Cellular Component	integral component of membrane (more)
Molecular Function	ATP binding (more)

GO Terms (all 27)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS No data available

INTERACTIONS AND PATHWAYS

SignaFish

ANTIBODIES

Name	Type	Isotype	Host Organism	Assay	Source	Publications
Ab1-pdgfrb	polyclonal		Rabbit	WB		1

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM pdgfrb

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(pdgfrb:EGFP,myl7:EGFP)	myl7, pdgfrb	EGFP	Danio rerio	1	1
TgBAC(pdgfrb:Citrine)	pdgfrb	Citrine	Danio rerio	1	4
TgBAC(pdgfrb:EGFP)	pdgfrb	EGFP	Danio rerio	2	7
TgBAC(pdgfrb:GAL4FF)	pdgfrb	GAL4FF	Danio rerio	2	4
TgBAC(pdgfrb:mCherry)	pdgfrb	mCherry	Danio rerio	1	2

MARKER RELATIONSHIPS No data available

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001190933 (1)	3195 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CABZ01112581 (1)	22588 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl
Polypeptide	UniProtKB:A0A2R8QHE8 (1)	1072 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 22)

ORTHOLOGY for pdgfrb ( Unmapped )

CITATIONS (54)

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