ZFIN ID: ZDB-GENE-030805-2
Gene Name: platelet-derived growth factor receptor, beta polypeptide
Gene Symbol: pdgfrb
Previous Name: pdgfrb2
Location: Chr: 14   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  central artery, dorsal aorta, dorsal longitudinal anastomotic vessel, floor plate neural tube (all 8) expand
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-pdgfrb (1), TALEN1-pdgfrb (1)

Allele Type Mutagen Suppliers
la027549Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16389 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa22413 Point Mutation ENU
    PHENOTYPE
    Data: Fig. 5 from Wiens et al., 2010
    Observed in: intersegmental vessel
    DISEASE ASSOCIATED WITH pdgfrb HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    basal ganglia calcification Basal ganglia calcification, idiopathic, 4 615007
    Myeloproliferative disorder with eosinophilia 131440
    Myofibromatosis, infantile, 1 228550
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR001824 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR016243 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR027288 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00240 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pdgfrb No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001190933 (1) 3195 bp
    Genomic GenBank:CABZ01112581 (1) 22588 bp
    Polypeptide UniProtKB:D9MNA7 (1) 1064 aa
    Sequence Clusters UniGene:159213 (1)
    Sequence Information (all 13)
    OTHER pdgfrb GENE PAGES
  • Gene:559529 (1)
  • Ensembl(Zv9):ENSDARG00000057345 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish pdgfrb 14  
    Human PDGFRB 5 (5q33.1)
  • OMIM:173410
  • Gene:5159
  • Mouse Pdgfrb 18 ( 34.41 cM)
  • MGI:97531
  • Gene:18596
  • Orthology Details
    CITATIONS (21)