ZFIN ID: ZDB-GENE-030805-2
Gene Name: platelet-derived growth factor receptor, beta polypeptide
Gene Symbol: pdgfrb    Nomenclature History

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Previous Name: pdgfrb2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Unmapped
Description: Predicted to have ATP binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in animal organ development and vasculature development. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma multiforme; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Is expressed in several structures, including blood vessel; floor plate neural tube; gut; hypochord; and somite. Orthologous to human PDGFRB (platelet derived growth factor receptor beta).
Genome Resources: Alliance (1),  Gene:559529 (1),  Ensembl(GRCz11):ENSDARG00000100897 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027549Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16389 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22413 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • um148 Small Deletion Unknown Frameshift, Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pdgfrb N/A 4
    TALEN1-pdgfrb 1
    DISEASE ASSOCIATED WITH pdgfrb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    basal ganglia calcification Alliance Basal ganglia calcification, idiopathic, 4 615007
    infantile myofibromatosis Alliance Myofibromatosis, infantile, 1 228550
    myeloproliferative disorder with eosinophilia Alliance Myeloproliferative disorder with eosinophilia 131440
    Kosaki overgrowth syndrome 616592
    Premature aging syndrome, Penttinen type 601812
    DISEASE ASSOCIATED WITH pdgfrb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cerebellum vasculature development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 28)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000719 Protein kinase domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
    Domain IPR003598 Immunoglobulin subtype 2
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR007110 Immunoglobulin-like domain
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Domain IPR013098 Immunoglobulin I-set
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-pdgfrb polyclonal Rabbit WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pdgfrb
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(pdgfrb:EGFP,myl7:EGFP) myl7pdgfrb EGFP Danio rerio 1 1
    TgBAC(pdgfrb:Citrine) pdgfrb Citrine Danio rerio 1 4
    TgBAC(pdgfrb:EGFP) pdgfrb EGFP Danio rerio 2 4
    TgBAC(pdgfrb:GAL4FF) pdgfrb GAL4FF Danio rerio 2 4
    TgBAC(pdgfrb:mCherry) pdgfrb mCherry Danio rerio 1 2
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001190933 (1) 3195 bp
    Genomic GenBank:CABZ01112581 (1) 22588 bp
    Polypeptide UniProtKB:A0A2R8QHE8 (1) 1072 aa
    Sequence Information (all 22)
    ORTHOLOGY for pdgfrb ( Unmapped )
    CITATIONS (49)