ZFIN ID: ZDB-GENE-030805-2 |
Gene Name: | platelet-derived growth factor receptor, beta polypeptide | ||||||
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Gene Symbol: | pdgfrb Nomenclature History | ||||||
Previous Name: | pdgfrb2 | ||||||
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Gene Type: | protein_coding_gene | ||||||
Location: | Unmapped | ||||||
Description: | Predicted to have ATP binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in animal organ development and vasculature development. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma multiforme; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Is expressed in several structures, including blood vessel; floor plate neural tube; gut; hypochord; and somite. Orthologous to human PDGFRB (platelet derived growth factor receptor beta). | ||||||
Genome Resources: | Alliance (1), Gene:559529 (1), Ensembl(GRCz11):ENSDARG00000100897 (1) |
Allele | Type | Localization | Consequence | Mutagen | Suppliers |
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la027549Tg | Transgenic Insertion | Unknown | Unknown | DNA |
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sa16389 | Point Mutation | Unknown | Premature Stop | ENU |
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sa22413 | Point Mutation | Unknown | Splice Site | ENU |
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um148 | Small Deletion | Unknown | Frameshift, Premature Stop | TALEN |
Targeting Reagent | Created Alleles | Publications |
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MO1-pdgfrb | N/A | 4 |
TALEN1-pdgfrb | 1 |
Data: | 3 figures from 3 publications |
Observed in: |
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
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basal ganglia calcification | Alliance | Basal ganglia calcification, idiopathic, 4 | 615007 |
infantile myofibromatosis | Alliance | Myofibromatosis, infantile, 1 | 228550 |
myeloproliferative disorder with eosinophilia | Alliance | Myeloproliferative disorder with eosinophilia | 131440 |
Kosaki overgrowth syndrome | 616592 | ||
Premature aging syndrome, Penttinen type | 601812 |
Ontology | GO Term |
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Biological Process | cerebellum vasculature development (more) |
Cellular Component | integral component of membrane (more) |
Molecular Function | ATP binding (more) |
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Name | Type | Isotype | Host Organism | Assay | Source | Publications |
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Ab1-pdgfrb | polyclonal | Rabbit | WB | 1 |
Construct | Regulatory Regions | Coding Sequences | Species | Tg Lines | Publications |
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Tg(pdgfrb:EGFP,myl7:EGFP) | myl7, pdgfrb | EGFP | Danio rerio | 1 | 1 |
TgBAC(pdgfrb:Citrine) | pdgfrb | Citrine | Danio rerio | 1 | 4 |
TgBAC(pdgfrb:EGFP) | pdgfrb | EGFP | Danio rerio | 2 | 4 |
TgBAC(pdgfrb:GAL4FF) | pdgfrb | GAL4FF | Danio rerio | 1 | 3 |
TgBAC(pdgfrb:mCherry) | pdgfrb | mCherry | Danio rerio | 1 | 2 |
Type | Accession # | Length (bp/aa) | Analysis |
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RNA | RefSeq:NM_001190933 (1) | 3195 bp |
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Genomic | GenBank:CABZ01112581 (1) | 22588 bp |
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Polypeptide | UniProtKB:A0A2R8QHE8 (1) | 1072 aa |
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Sequence Clusters | UniGene:159213 (1) |