Gene

pdgfrb

ID

ZDB-GENE-030805-2

Name

platelet-derived growth factor receptor, beta polypeptide

Symbol

pdgfrb Nomenclature History

Previous Names

pdgfrb2

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have ATP binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in animal organ development and vasculature development. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma multiforme; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Is expressed in several structures, including blood vessel; floor plate neural tube; gut; hypochord; and somite. Orthologous to human PDGFRB (platelet derived growth factor receptor beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

21 figures from 15 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UCSC scRNA-seq

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pdgfrb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
basal ganglia calcification	Alliance	Basal ganglia calcification, idiopathic, 4	615007
infantile myofibromatosis	Alliance	Myofibromatosis, infantile, 1	228550
myeloproliferative disorder with eosinophilia	Alliance	Myeloproliferative disorder with eosinophilia	131440
		Kosaki overgrowth syndrome	616592
		Premature aging syndrome, Penttinen type	601812

Associated With pdgfrb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Conserved_site	IPR001824	Tyrosine-protein kinase, receptor class III, conserved site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin subtype	Immunoglobulin subtype 2	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, receptor class III, conserved site
UniProtKB:A0A0G2L2B8 InterPro	877
UniProtKB:D9MNA7 InterPro	1064
UniProtKB:Q8JHY2 InterPro	63
UniProtKB:A0A2R8QHE8 InterPro	1072

Transcripts

Genome Browsers: No data available

No data available

Interactions and Pathways

SignaFish

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-pdgfrb	polyclonal	pdgfrb		Rabbit	WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations