ZFIN ID: ZDB-GENE-030804-1
Gene Name: tenascin R (restrictin, janusin)
Gene Symbol: tnr    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Involved in axon guidance. Predicted to localize to the collagen-containing extracellular matrix. Is expressed in brain; diencephalon; head; optic tectum; and retinal outer plexiform layer. Orthologous to human TNR (tenascin R).
Genome Resources: Alliance (1),  Gene:369191 (1),  Ensembl(GRCz11):ENSDARG00000020771 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Wild-type Stages, Structures: Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014925Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la023629Tg Transgenic Insertion Unknown Unknown DNA
    sa6854 Point Mutation Unknown Premature Stop ENU
    sa30599 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31286 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44538 Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tnr N/A 1
    MO2-tnr N/A 1
    PHENOTYPE
    Data: Fig. 4 from Becker et al., 2003
    Observed in:
    DISEASE ASSOCIATED WITH tnr HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tnr VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon guidance (more)
    Cellular Component collagen-containing extracellular matrix (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000742 EGF-like domain
    Domain IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    Domain IPR003961 Fibronectin type III
    Conserved_site IPR013032 EGF-like, conserved site
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Conserved_site IPR020837 Fibrinogen, conserved site
    Family IPR033079 Tenascin-R
    Homologous_superfamily IPR036056 Fibrinogen-like, C-terminal
    Homologous_superfamily IPR036116 Fibronectin type III superfamily
    Domain IPR041161 Tenascin, EGF-like domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tnr-201 (1)    Ensembl 5056
    tnr-202 (1)    Ensembl 468
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tnr IHC, WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tnr No data available
    MARKER RELATIONSHIPS
    tnr Contained in: [BAC] CH73-9B13 (1), CH73-12O5 (1), CH73-100G16 (1), CH211-214F1 (1), DKEY-147D11 (1) (order this)
    tnr Encodes: [cDNA] MGC:193575 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_194383 (1) 4933 bp
    Genomic GenBank:CT027627 (1) 177228 bp
    Select Tool
    Polypeptide UniProtKB:A2CF37 (1) 1350 aa
    Sequence Information (all 22)
    ORTHOLOGY for tnr ( Chr: 2 )
    CITATIONS (24)