Gene

tgfb2

ID

ZDB-GENE-030723-3

Name

transforming growth factor, beta 2

Symbol

tgfb2 Nomenclature History

Previous Names

tgf beta 2 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have cytokine activity; type II transforming growth factor beta receptor binding activity; and type III transforming growth factor beta receptor binding activity. Involved in roof of mouth development and sclerotome development. Predicted to localize to extracellular space. Is expressed in several structures, including mandibular arch skeleton; mesoderm; otic placode; pericardial region; and periocular mesenchyme. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4 and colorectal cancer. Orthologous to human TGFB2 (transforming growth factor beta 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

23 figures from 16 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tgfb2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Loeys-Dietz syndrome 4	Alliance	Loeys-Dietz syndrome 4	614816

Associated With tgfb2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017948	Transforming growth factor beta, conserved site
Domain	IPR001111	TGF-beta, propeptide
Domain	IPR001839	Transforming growth factor-beta, C-terminal
Family	IPR003940	Transforming growth factor beta-2 proprotein
Family	IPR015615	Transforming growth factor-beta-related
Family	IPR016319	Transforming growth factor-beta
Homologous_superfamily	IPR029034	Cystine-knot cytokine