Gene

tgfb2

ID
ZDB-GENE-030723-3
Name
transforming growth factor, beta 2
Symbol
tgfb2 Nomenclature History
Previous Names
  • tgf beta 2 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have cytokine activity; type II transforming growth factor beta receptor binding activity; and type III transforming growth factor beta receptor binding activity. Involved in roof of mouth development and sclerotome development. Predicted to localize to extracellular space. Is expressed in several structures, including mandibular arch skeleton; mesoderm; otic placode; pericardial region; and periocular mesenchyme. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4 and colorectal cancer. Orthologous to human TGFB2 (transforming growth factor beta 2).
Genome Resources
Note
None
Expression
All Expression Data
18 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tgfb2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Loeys-Dietz syndrome 4 Alliance Loeys-Dietz syndrome 4 614816
Associated With tgfb2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001111 TGF-beta, propeptide
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR003940 Transforming growth factor beta-2 proprotein
Family IPR015615 Transforming growth factor-beta-related
Family IPR016319 Transforming growth factor-beta
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine TGF-beta, propeptide Transforming growth factor-beta Transforming growth factor beta-2 proprotein Transforming growth factor beta, conserved site Transforming growth factor-beta, C-terminal Transforming growth factor-beta-related
UniProtKB:F8W4A6 413
UniProtKB:Q7SZV4 411
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations