Gene
tgfb2
- ID
- ZDB-GENE-030723-3
- Name
- transforming growth factor, beta 2
- Symbol
- tgfb2 Nomenclature History
- Previous Names
-
- tgf beta 2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have cytokine activity; type II transforming growth factor beta receptor binding activity; and type III transforming growth factor beta receptor binding activity. Involved in roof of mouth development and sclerotome development. Predicted to localize to extracellular space. Is expressed in several structures, including mandibular arch skeleton; mesoderm; otic placode; pericardial region; and periocular mesenchyme. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4 and colorectal cancer. Orthologous to human TGFB2 (transforming growth factor beta 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Loeys-Dietz syndrome 4 | Alliance | Loeys-Dietz syndrome 4 | 614816 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
Domain | IPR001111 | TGF-beta, propeptide |
Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
Family | IPR003940 | Transforming growth factor beta-2 proprotein |
Family | IPR015615 | Transforming growth factor-beta-related |
Family | IPR016319 | Transforming growth factor-beta |
Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
Domain Details Per Protein
Protein | Length | Cystine-knot cytokine | TGF-beta, propeptide | Transforming growth factor-beta | Transforming growth factor beta-2 proprotein | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q7SZV4
|
411 | |||||||
UniProtKB:F8W4A6
|
413 |
Interactions and Pathways
No data available
Plasmids
No data available