ZFIN Gene: tgfb2

ZFIN ID: ZDB-GENE-030723-3

ZFIN ID: ZDB-GENE-030723-3

Gene Name:

transforming growth factor, beta 2

Gene Symbol:

tgfb2

Sequence Ontology ID :

SO:0000704

Previous Name:

tgf beta 2 (1)

Location:

Chr: 16 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have cytokine activity and type II transforming growth factor beta receptor binding activity. Involved in hard palate development and sclerotome development. Predicted to localize to the ...

GENE EXPRESSION
All Expression Data:	16 figures from 9 publications
Directly Submitted Expression Data:	5 figures (8 images) from Chen et al., 2003 [tgf_beta_2]
Wild-type Stages, Structures:	Gastrula:Bud (10.0h-10.33h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	fin mandibular arch skeleton cranial neural crest cell mandibular arch skeleton maxilla cranial neural crest cell mesoderm notochord otic placode otic vesicle periocular mesenchyme pharynx polster presumptive cardiac ventricle heart tube presumptive neural retina primitive heart tube solid lens vesicle tail bud unspecified

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Targeting reagents:

PHENOTYPE

Data:	2 figures from 2 publications
Observed in:	ethmoid cartilage mandibular arch skeleton Meckel's cartilage neural tube palate parasphenoid sclerotome trabecula cranii

DISEASE ASSOCIATED WITH tgfb2 HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
Loeys-Dietz syndrome 4	Loeys-Dietz syndrome 4	614816

DISEASE ASSOCIATED WITH tgfb2 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	hard palate development (more)
Cellular Component	extracellular region (more)
Molecular Function	growth factor activity (more)

GO Terms (all 17)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR001111 (1) InterPro:IPR001839 (1) InterPro:IPR003940 (1) InterPro:IPR015615 (1) InterPro:IPR016319 (1) InterPro:IPR017948 (1) InterPro:IPR029034 (1)	PROSITE:PS00250 (1) PROSITE:PS51362 (1)	Pfam:PF00019 (1) Pfam:PF00688 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	tgfb2-201 (1)	1242	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM tgfb2 No data available

MARKER RELATIONSHIPS

tgfb2Contained in:	[BAC] CH211-65B3 (1) (order this), DKEY-288I20 (1) (order this)
tgfb2Encodes:	[EST] tgf_beta_2 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_194385 (1)	1242bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU207260 (1)	172886bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F8W4A6 (1)	413aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:89477 (1)

Sequence Information (all 11)

OTHER tgfb2 GENE PAGES

Alliance (1)

Gene:369194 (1)

VEGA:OTTDARG00000033939 (1)

Ensembl(GRCz11):ENSDARG00000027087 (2)

ORTHOLOGY for tgfb2 (Chr: 16)

CITATIONS (41)

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