ZFIN Gene: fgf10a

ZFIN ID: ZDB-GENE-030715-1

ZFIN ID: ZDB-GENE-030715-1

Gene Name:

fibroblast growth factor 10a

Gene Symbol:

fgf10a Nomenclature History

Previous Names:

fgf10, dae, daedalus, wu:fd11d03 (1), zgc:109774

Gene Type:

protein_coding_gene

Location:

Chr: 21 Mapping Details/Browsers

Description:

Predicted to have fibroblast growth factor receptor binding activity and growth factor activity. Involved in several processes, including embryonic pectoral fin morphogenesis; posterior lateral line development; and regulation of hematopoietic stem cell differentiation. Predicted to localize to extracellular region. Is expressed in several structures, including ectoderm; fin bud; gut; head; and lateral line system. Human ortholog(s) of this gene implicated in LADD syndrome and aplasia of lacrimal and salivary glands. Orthologous to human FGF10 (fibroblast growth factor 10).

Genome Resources:

Alliance (1), Gene:359830 (1), Ensembl(GRCz11):ENSDARG00000030932 (1)

GENE EXPRESSION
All Expression Data:	90 figures from 52 publications
Directly Submitted Expression Data:	6 figures (13 images) from Thisse et al., 2004 [MGC:109774]
	7 figures (19 images) from Thisse et al., 2005 [eu110]
Wild-type Stages, Structures:	Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Days 21-29 (21d-30d, 7.8mm, 10 teeth)
	anterior lateral line anterior lateral line neuromast anterior lateral line placode anterior macula esophagus fin bud gut intestinal bulb lateral line lateral line ganglion lateral line primordium lateral line system mandibular arch skeleton cranial neural crest cell maxilla cranial neural crest cell mesenchymal cell mesenchyme mesenchyme pectoral fin mesoderm pectoral fin bud neuromast neuromast hair cell olfactory placode olfactory region cranial neural crest cell oral ectoderm oral region ectoderm otic placode anterior region otic placode otic vesicle anterior crista otic vesicle anterior region otic vesicle lateral crista otic vesicle posterior crista otic vesicle posterior region otic vesicle paired fin pancreatic system mesenchyme pectoral fin pectoral fin bud mesenchyme pectoral fin bud pectoral fin field lateral plate mesoderm pectoral fin field pelvic fin bud mesenchyme periderm pharyngeal arch pharyngeal arch 3-7 posterior lateral line neuromast posterior lateral line placode posterior lateral line primordium posterior lateral plate mesoderm protoneuromast central region swim bladder mesenchyme swim bladder swim bladder bud mesenchyme tail bud trunk unspecified whole organism
High Throughput Expression:	GEO (1) Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa23903	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
t24030	Point Mutation	Unknown	Missense	ENU
tbvbo	Point Mutation	Unknown	Premature Stop	ENU

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-fgf10a	N/A	4
MO2-fgf10a	N/A	1
MO3-fgf10a	N/A	5
MO4-fgf10a	N/A	2

PHENOTYPE

Data:

17 figures from 11 publications

Observed in:

DISEASE ASSOCIATED WITH fgf10a HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
aplasia of lacrimal and salivary glands	Alliance	Aplasia of lacrimal and salivary glands	180920
LADD syndrome	Alliance	LADD syndrome	149730

DISEASE ASSOCIATED WITH fgf10a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	liver development (more)
Cellular Component	extracellular region (more)
Molecular Function	fibroblast growth factor receptor binding (more)

GO Terms (all 29)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	fgf10a-201 (1)	2005	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM fgf10a

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
tg(hsp70l:fgf10a)	hsp70l	fgf10a	Danio rerio	1	1
Tg(hsp70l:fgf10a-EGFP)	hsp70l	EGFP, fgf10a	Danio rerio	1	1
tgbac(fgf10a:egfp-fgf10a,cryaa:dsred)	cryaa, fgf10a	DsRed, EGFP, fgf10a	Danio rerio	1	1
tgbac(fgf10a:sec-egfp,cryaa:dsred)	cryaa, fgf10a	DsRed, EGFP, SEC	Danio rerio	1	1

MARKER RELATIONSHIPS

fgf10a Contained in:	[BAC] CH211-262I10 (1)
fgf10a Encodes:	[EST] eu110 (1), fd11d03 (1) [cDNA] MGC:109774, MGC:192178 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_182870 (1)	2017 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX927394 (1)	164899 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q4VBV7 (1)	201 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 19)

ORTHOLOGY for fgf10a ( Chr: 21 )

CITATIONS (129)

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