Gene
fgf10a
- ID
- ZDB-GENE-030715-1
- Name
- fibroblast growth factor 10a
- Symbol
- fgf10a Nomenclature History
- Previous Names
-
- fgf10
- dae
- daedalus
- wu:fd11d03 (1)
- zgc:109774
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Is predicted to enable chemoattractant activity; growth factor activity; and type 2 fibroblast growth factor receptor binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and secretion by lung epithelial cell involved in lung growth. Acts upstream of or within several processes, including embryonic pectoral fin morphogenesis; posterior lateral line development; and regulation of hematopoietic stem cell differentiation. Predicted to be located in extracellular region. Is expressed in several structures, including ectoderm; fin bud; gut; head; and lateral line system. Human ortholog(s) of this gene implicated in LADD syndrome and aplasia of lacrimal and salivary glands. Orthologous to human FGF10 (fibroblast growth factor 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 94 figures from 56 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109774 (13 images)
- eu110 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| aplasia of lacrimal and salivary glands | Alliance | Aplasia of lacrimal and salivary glands | 180920 |
| LADD syndrome | Alliance | LADD syndrome | 149730 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytokine IL1/FGF | Fibroblast growth factor 10 | Fibroblast growth factor family |
|---|---|---|---|---|
|
UniProtKB:Q4VBV7
|
201 | |||
|
UniProtKB:Q8AY90
|
201 | |||
|
UniProtKB:Q800L8
|
191 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
fgf10a-201
(1)
|
2005 nt |
Interactions and Pathways
No data available
Plasmids
No data available