ZFIN ID: ZDB-GENE-030619-9
Gene Name: cathepsin C
Gene Symbol: ctsc    Nomenclature History

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Previous Names: cb912 (1), ik:tdsubc_1h2 (1), sb:cb146, wu:fb34g12, wu:fj58d01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to localize to extracellular space and lysosome. Is expressed in macrophage; neural crest; polster; somite; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Orthologous to human CTSC (cathepsin C).
Genome Resources: Alliance (1),  Gene:368704 (1),  Ensembl(GRCz11):ENSDARG00000101334 (1)
GENE EXPRESSION
All Expression Data: 13 figures from 3 publications
Directly Submitted Expression Data: 5 figures (4 images) from Thisse et al., 2001 [cb146]
  6 figures (12 images) from Thisse et al., 2001 [cb912]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ctsc HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
aggressive periodontitis Alliance Periodontitis 1, juvenile 170650
Papillon-Lefevre disease Alliance Papillon-Lefevre syndrome 245000
Haim-Munk syndrome 245010
DISEASE ASSOCIATED WITH ctsc VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process proteolysis (more)
Cellular Component extracellular space (more)
Molecular Function cysteine-type peptidase activity (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ctsc No data available
MARKER RELATIONSHIPS
ctsc Contains: [SNP] rs3728752 (1)
ctsc Encodes: [EST] cb146 (order this), cb912 (1) (order this), fb34g12, fj58d01, tdsubc_1h2
[cDNA] MGC:77609 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_214722 (1)
Polypeptide UniProtKB:A0A0R4IK18 (1) 455 aa
Sequence Information (all 16)
ORTHOLOGY for ctsc ( Chr: 15 )
CITATIONS (28)