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Gene

ctsc

ID
ZDB-GENE-030619-9
Name
cathepsin C
Symbol
ctsc Nomenclature History
Previous Names
  • cb912 (1)
  • ik:tdsubc_1h2 (1)
  • sb:cb146
  • wu:fb34g12
  • wu:fj58d01
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space and lysosome. Is expressed in macrophage; neural crest; polster; somite; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Orthologous to human CTSC (cathepsin C).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ctsc Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
aggressive periodontitis Alliance Periodontitis 1, juvenile 170650
Papillon-Lefevre disease Alliance Papillon-Lefevre syndrome 245000
Haim-Munk syndrome 245010
Associated With ctsc Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR000169 Cysteine peptidase, cysteine active site
Active_site IPR025660 Cysteine peptidase, histidine active site
Active_site IPR025661 Cysteine peptidase, asparagine active site
Domain IPR000668 Peptidase C1A, papain C-terminal
Domain IPR014882 Cathepsin C exclusion
Domain IPR039412 Cathepsin C
Homologous_superfamily IPR036496 Cathepsin C, exclusion domain superfamily
Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
Domain Details Per Protein
Protein Length Cathepsin C Cathepsin C exclusion Cathepsin C, exclusion domain superfamily Cysteine peptidase, asparagine active site Cysteine peptidase, cysteine active site Cysteine peptidase, histidine active site Papain-like cysteine peptidase superfamily Peptidase C1A, papain C-terminal
UniProtKB:A0A0R4IK18 455
UniProtKB:Q6P2V1 455
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations