ZFIN ID: ZDB-GENE-030616-622
Gene Name: ADAM metallopeptidase domain 8a
Gene Symbol: adam8a    Nomenclature History

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Previous Names: adam8, CD156a (1), si:zc217g15.7, zgc:64059

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits metallopeptidase activity and protease binding activity. Predicted to be involved in integrin-mediated signaling pathway and proteolysis. Predicted to localize to the integral component of membrane. Is expressed in several structures, including axial vasculature; intermediate cell mass of mesoderm; macrophage; tail bud; and yolk. Orthologous to human ADAM8 (ADAM metallopeptidase domain 8).
Genome Resources: Alliance (1),  Gene:368917 (1),  Ensembl(GRCz11):ENSDARG00000001452 (2)
DISEASE ASSOCIATED WITH adam8a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH adam8a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process integrin-mediated signaling pathway (more)
Cellular Component integral component of membrane (more)
Molecular Function metallopeptidase activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Domain IPR001590 Peptidase M12B, ADAM/reprolysin
Domain IPR001762 Disintegrin domain
Domain IPR002870 Peptidase M12B, propeptide
Domain IPR006586 ADAM, cysteine-rich domain
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018358 Disintegrin, conserved site
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Domain IPR034027 Reprolysin domain, adamalysin-type
Homologous_superfamily IPR036436 Disintegrin domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA adam8a-201 (1)    Ensembl 3251
ncRNA adam8a-002 (1)    Ensembl 650
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM adam8a No data available
MARKER RELATIONSHIPS
adam8a Contained in: [BAC] CH211-217G15 (1), CH211-223P8 (1)
adam8a Encodes: [EST] IMAGE:7148247 (1)
[cDNA] MGC:64059 (1), MGC:192762 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_200637 (1) 3304 bp
Genomic GenBank:AL929005 (1) 166364 bp
Select Tool
Polypeptide UniProtKB:Q7ZYZ9 (1) 843 aa
Sequence Information (all 14)
ORTHOLOGY for adam8a ( Chr: 13 )
CITATIONS (26)