Gene

adam8a

ID
ZDB-GENE-030616-622
Name
ADAM metallopeptidase domain 8a
Symbol
adam8a Nomenclature History
Previous Names
  • adam8
  • CD156a (1)
  • si:zc217g15.7
  • zgc:64059
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Exhibits metallopeptidase activity and protease binding activity. Predicted to be involved in several processes, including inflammatory response; positive regulation of cellular extravasation; and positive regulation of membrane protein ectodomain proteolysis. Predicted to colocalize with alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex. Is expressed in several structures, including axial vasculature; intermediate cell mass of mesoderm; macrophage; tail bud; and yolk. Orthologous to human ADAM8 (ADAM metallopeptidase domain 8).
Genome Resources
Note
None
Expression
All Expression Data
8 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. 3 from Iida et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adam8a Human Ortholog
No data available
Associated With adam8a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018358 Disintegrin, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001590 Peptidase M12B, ADAM/reprolysin
Domain IPR001762 Disintegrin domain
Domain IPR002870 Peptidase M12B, propeptide
Domain IPR006586 ADAM, cysteine-rich domain
Domain IPR034027 Reprolysin domain, adamalysin-type
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR036436 Disintegrin domain superfamily
Domain Details Per Protein
Protein Length ADAM, cysteine-rich domain Disintegrin, conserved site Disintegrin domain Disintegrin domain superfamily EGF-like domain Metallopeptidase, catalytic domain superfamily Peptidase M12B, ADAM/reprolysin Peptidase M12B, propeptide Reprolysin domain, adamalysin-type
UniProtKB:Q7ZYZ9 843
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations