ZFIN ID: ZDB-GENE-030616-614
Gene Name: ribonucleotide reductase M2 b
Gene Symbol: rrm2b    Nomenclature History

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Previous Names: fb72h01, fb93b05, si:zc215i13.5, wu:fb72h01, wu:fb93b05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in cellular response to DNA damage stimulus. Localizes to cytoplasm. Is expressed in several structures, including brain; eye; liver; otic vesicle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B).
Genome Resources: Alliance (1),  Gene:368909 (1),  Ensembl(GRCz11):ENSDARG00000033367 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17865 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH rrm2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5 Alliance Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 5 613077
    mitochondrial DNA depletion syndrome 8a Alliance Mitochondrial DNA depletion syndrome 8A (encephalomyopathic type with renal tubulopathy) 612075
    Mitochondrial DNA depletion syndrome 8B (MNGIE type) 612075
    mitochondrial DNA depletion syndrome 8b Alliance Mitochondrial DNA depletion syndrome 8A (encephalomyopathic type with renal tubulopathy) 612075
    Mitochondrial DNA depletion syndrome 8B (MNGIE type) 612075
    DISEASE ASSOCIATED WITH rrm2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to DNA damage stimulus (more)
    Cellular Component cytoplasm (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rrm2b-202 (1)    Ensembl 1289
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rrm2b No data available
    MARKER RELATIONSHIPS
    rrm2b Contained in: [BAC] CH211-215I13 (1)
    rrm2b Encodes: [EST] fb72h01, fb93b05
    [cDNA] MGC:123064 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001007163 (1) 1613 nt
    Genomic GenBank:AL807244 (1) 201745 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q32PP6 (1) 349 aa
    Sequence Information (all 15)
    ORTHOLOGY for rrm2b ( Chr: 19 )
    CITATIONS (27)