ZFIN ID: ZDB-GENE-030616-585
Gene Name: protein arginine methyltransferase 5
Gene Symbol: prmt5    Nomenclature History

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Previous Names: PRMT5 (1), si:zc14a17.2, skb1 (1), wu:fb95f10, zgc:110669

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have histone-arginine N-methyltransferase activity. Involved in regulation of skeletal muscle fiber development. Predicted to localize to cytosol and nucleus. Is expressed in segmental plate; shield; and somite. Orthologous to human PRMT5 (protein arginine methyltransferase 5).
Genome Resources: Alliance (1),  Gene:368664 (1),  Ensembl(GRCz11):ENSDARG00000079605 (1)
GENE EXPRESSION
All Expression Data: 2 figures from Batut et al., 2011
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb228 Indel Exon 3 Unknown CRISPR
ihb229 Indel Exon 3 Unknown CRISPR
ihb1994 Small Deletion Unknown Unknown CRISPR
ihb1995 Small Deletion Unknown Unknown CRISPR
sa13211 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15882 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38347 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-prmt5 1
    CRISPR3-prmt5 1
    MO1-prmt5 N/A 1
    MO2-prmt5 N/A 1
    DISEASE ASSOCIATED WITH prmt5 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH prmt5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of skeletal muscle fiber development (more)
    Cellular Component cytoplasm (more)
    Molecular Function S-adenosylmethionine-dependent methyltransferase activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-prmt5 polyclonal IgG Rabbit WB Millipore
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prmt5 No data available
    MARKER RELATIONSHIPS
    prmt5 Contained in: [BAC] CH211-14A17 (1)
    prmt5 Encodes: [EST] fb95f10
    [cDNA] MGC:110669 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001007183 (1) 2491 nt
    Genomic GenBank:AL772295 113150 nt
    Select Tool
    Polypeptide UniProtKB:B0R026 (1) 631 aa
    Sequence Information (all 16)
    ORTHOLOGY for prmt5 ( Chr: 2 )
    CITATIONS (32)