ZFIN ID: ZDB-GENE-030616-579
Gene Name: pancreas specific transcription factor, 1a
Gene Symbol: ptf1a
Previous Names: Ptfa (1), si:zc142h2.2, zgc:112216
Location: Chr: 2   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 47 figures from 29 publications
Directly Submitted Expression Data: 6 figures (18 images) from Thisse et al., 2005 [eu536]
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Adult (90d-730d, breeding adult)
  anterior pancreatic bud, central nervous system amacrine cell, cerebellum, cerebellum ventricular zone (all 21) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 5 genotypes
Alleles: s922, sa126
Knockdown reagents: MO1-ptf1a (1), MO2-ptf1a (1), MO3-ptf1a (1), MO4-ptf1a (1)
PHENOTYPE
Data: 6 figures from 4 publications
Observed in: anterior pancreatic bud, exocrine cell, exocrine pancreas, exocrine pancreas development (all 7) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Pancreatic agenesis 2 615935
Pancreatic and cerebellar agenesis 609069
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of transcription, DNA-templated (more)
Cellular Component cytoplasm (more)
Molecular Function sequence-specific DNA binding (more)
GO Terms (all 19)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR011598 (1)
  • PROSITE:PS50888 (1)
  • Pfam:PF00010 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ptf1a-001 (1) 798
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ptf1a
    Tg(-5.5ptf1a:DsRed), Tg(hsp70l:LOXP-EBFP2-LOXP-ptf1a-Dme.En,cryaa:Cerulean), Tg(pft1a:GAL4-VP16), Tg(ptf1a:EGFP), Tg(ptf1a:EGFP-Hsa.KRAS_G12V) (all 11) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ptf1a Contained in: [BAC] CH211-142H2 (1) (order this)
    ptf1a Encodes: [EST] eu536 (1)
    [cDNA] MGC:112216 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_207641 (1) 1211 bp
    Genomic GenBank:AL845362 (1) 161465 bp
    Select Tool
    Polypeptide UniProtKB:Q7ZSX3 (1) 265 aa
    Sequence Clusters UniGene:86563 (1)
    Sequence Information (all 14)
    OTHER ptf1a GENE PAGES
  • Gene:368662 (1)
  • VEGA:OTTDARG00000001954 (1)
  • Ensembl(Zv9):ENSDARG00000014479 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA
    Zebrafish ptf1a 2  
    Human PTF1A 10 (10p12.2)
  • OMIM:607194
  • Gene:256297
  • Mouse Ptf1a 2 ( 13.37 cM)
  • MGI:1328312
  • Gene:19213
  • Orthology Details
    CITATIONS (72)