ZFIN ID: ZDB-GENE-030616-579
Gene Name: pancreas specific transcription factor, 1a
Gene Symbol: ptf1a
Previous Names: Ptfa (1), si:zc142h2.2, zgc:112216
Location: Chr: 2 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 60 figures from 35 publications
Directly Submitted Expression Data: 6 figures (18 images) from Thisse et al., 2005 [eu536]
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Adult (90d-730d, breeding adult)
  amacrine cell, anterior pancreatic bud, brain, central nervous system amacrine cell (all 29) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
s922 Point Mutation Unknown Missense ENU
sa126 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-ptf1a (1), MO2-ptf1a (1), MO3-ptf1a (1), MO4-ptf1a (1)
    PHENOTYPE
    Data: 6 figures from 4 publications
    Observed in: anterior pancreatic bud, exocrine cell, exocrine pancreas, exocrine pancreas development (all 7) expand
    DISEASE ASSOCIATED WITH ptf1a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Pancreatic and cerebellar agenesis 609069
    Pancreatic agenesis 2 615935
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of transcription, DNA-templated (more)
    Cellular Component cytoplasm (more)
    Molecular Function sequence-specific DNA binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR011598 (1)
  • PROSITE:PS50888 (1)
  • Pfam:PF00010 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ptf1a-001 (1) 798
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ptf1a
    Tg(-5.5ptf1a:DsRed), Tg(hsp70l:LOXP-EBFP2-LOXP-ptf1a-Dme.En,cryaa:Cerulean), Tg(ptf1a:EGFP), Tg(ptf1a:EGFP-Hsa.KRAS_G12V), Tg1(ptf1a-Mmu.Fos:EGFP) (all 12) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ptf1aContained in: [BAC] CH211-142H2 (1) (order this)
    ptf1aEncodes: [EST] eu536 (1)
    [cDNA] MGC:112216 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_207641 (1) 1211bp
    Genomic GenBank:AL845362 (1) 161465bp
    Select Tool
    Polypeptide UniProtKB:Q7ZSX3 (1) 265aa
    Sequence Clusters UniGene:86563 (1)
    Sequence Information (all 14)
    OTHER ptf1a GENE PAGES
  • Gene:368662 (1)
  • VEGA:OTTDARG00000001954 (1)
  • Ensembl(GRCz10):ENSDARG00000014479 (1)
  • ORTHOLOGY for ptf1a (Chr: 2)
    Species Symbol Chromosome Accession # Evidence
    Human PTF1A 10
  • Gene:256297
  • OMIM:607194
  • HGNC:23734
  • Amino acid sequence comparison (2)
    Mouse Ptf1a 2
  • MGI:1328312
  • Gene:19213
  • Amino acid sequence comparison (2)
    Download Curated Orthology
    CITATIONS (80)