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ZIRC
ZFIN ID: ZDB-GENE-030616-47
Gene Name: phosphatase and tensin homolog B
Gene Symbol: ptenb    Nomenclature History

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Previous Names: pten, fa11a08, fb73f10, fc83f12, fd16b10, fk90e11, si:bz1g13.4, wu:fa11a08, wu:fb73f10, wu:fc83f12, wu:fd16b10, wu:fk90e11

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Exhibits lipid phosphatase activity. Involved in several processes, including lifelong otolith mineralization; phosphatidylinositol dephosphorylation; and regulation of protein kinase B signaling. Predicted to localize to the PML body and cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; breast cancer (multiple); fatty liver disease; macrocephaly-autism syndrome; and nervous system cancer (multiple). Is expressed in several structures, including adaxial cell; nervous system; neural rod; pectoral fin; and pharyngeal arch. Orthologous to human PTEN (phosphatase and tensin homolog).
Genome Resources: Alliance (1),  Gene:368415 (1),  Ensembl(GRCz11):ENSDARG00000056623 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu1435 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018072Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018073Tg Transgenic Insertion Unknown Unknown DNA
    sa17852 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44756 Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ptenb
    1
    MO1-ptenb N/A 4
    MO2-ptenb N/A 2
    MO3-ptenb N/A 1
    DISEASE ASSOCIATED WITH ptenb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Bannayan-Riley-Ruvalcaba syndrome Alliance Cowden syndrome 1 158350
    Lhermitte-Duclos syndrome 158350
    macrocephaly-autism syndrome Alliance Macrocephaly/autism syndrome 605309
    prostate cancer Alliance Prostate cancer, somatic 176807
    {Glioma susceptibility 2} 613028
    {Meningioma} 607174
    DISEASE ASSOCIATED WITH ptenb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphatidylinositol dephosphorylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function lipid phosphatase activity (more)
    GO Terms (all 26)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ptenb-201 (1)    Ensembl 1947
    ptenb-202 (1)    Ensembl 3380
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ptenb No data available
    MARKER RELATIONSHIPS
    ptenb Contained in: [BAC] RP71-1G13 (1) (order this)
    ptenb Encodes: [EST] fa11a08, fb73f10, fc83f12, fd16b10, fk90e11, IMAGE:7163207 (1) (order this)
    [cDNA] MGC:123112 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001001822 (1) 2602 bp
    Genomic GenBank:AL731788 (1) 165909 bp
    Select Tool
    Polypeptide UniProtKB:Q6TGR5 (1) 422 aa
    Sequence Clusters UniGene:150341 (1)
    Sequence Information (all 28)
    ORTHOLOGY for ptenb ( Chr: 12 )
    CITATIONS (62)