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Gene

mhc2d8.35b2

ID
ZDB-GENE-030616-171
Name
major histocompatibility complex class II d8.35b2
Symbol
mhc2d8.35b2 Nomenclature History
Previous Names
  • si:busm1-160c18.3 (1)
  • si:dkey-33b17.3 (1)
  • si:dz160c18.3
  • zgc:158775
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable MHC class II protein complex binding activity. Predicted to be involved in antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Predicted to act upstream of or within antigen processing and presentation and immune response. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of MHC class II protein complex. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and sarcoidosis (multiple). Orthologous to several human genes including HLA-DQB2 (major histocompatibility complex, class II, DQ beta 2) and HLA-DRB5 (major histocompatibility complex, class II, DR beta 5).
Genome Resources
Note
novel protein similar to MHC class II beta chain
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mhc2d8.35b2 Human Ortholog
No data available
Associated With mhc2d8.35b2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000353 MHC class II, beta chain, N-terminal
Domain IPR003597 Immunoglobulin C1-set
Domain IPR007110 Immunoglobulin-like domain
Homologous_superfamily IPR011162 MHC classes I/II-like antigen recognition protein
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014745 MHC class II, alpha/beta chain, N-terminal
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin C1-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold MHC classes I/II-like antigen recognition protein MHC class II, alpha/beta chain, N-terminal MHC class II, beta chain, N-terminal
UniProtKB:F1QNN2 130
UniProtKB:A1L2B8 130
UniProtKB:Q8MGR7 248
UniProtKB:A0A0R4IRA8 277
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations