timp2a

ID

ZDB-GENE-030612-1

Name

TIMP metallopeptidase inhibitor 2a

Symbol

timp2a Nomenclature History

Previous Names

timp2
TIMP2a (1)
etID32613.12 (1)
fa96h09
wu:fa96h09 (1)
zgc:136726

Type

protein_coding_gene

Location

Ambiguous Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable metalloendopeptidase inhibitor activity. Predicted to be involved in negative regulation of membrane protein ectodomain proteolysis; response to cytokine; and response to hormone. Predicted to act upstream of or within negative regulation of peptidase activity. Located in extracellular space. Is expressed in several structures, including brain; heart; liver; post-vent region; and trunk. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 14 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Zhang et al., 2003
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With timp2a Human Ortholog

No data available

Associated With timp2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR030490	Tissue inhibitor of metalloproteinase, conserved site
Domain	IPR001134	Netrin domain
Family	IPR001820	Protease inhibitor I35 (TIMP)
Homologous_superfamily	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily	IPR027465	Proteinase inhibitor I35b (TIMP), C-terminal