Gene
pomca
- ID
- ZDB-GENE-030513-2
- Name
- proopiomelanocortin a
- Symbol
- pomca Nomenclature History
- Previous Names
-
- pomc
- ACTH
- beta-endorphin
- MSH
- si:bz36d5.2
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Exhibits neuropeptide hormone activity. Involved in several processes, including melanosome localization; multicellular organismal response to stress; and regulation of hematopoietic stem cell differentiation. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in familial Mediterranean fever; obesity; and osteoarthritis. Is expressed in several structures, including adenohypophyseal placode; adrenal medulla cell; diencephalon; endocrine cell; and male organism. Orthologous to human POMC (proopiomelanocortin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 115 figures from 69 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hyperandrogenism | pomcaihb408/ihb408 | standard conditions | Shi et al., 2019 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Opiodes neuropeptide | Pro-opiomelanocortin | Pro-opiomelanocortin/corticotropin, ACTH, central region | Pro-opiomelanocortin-derived peptides | Pro-opiomelanocortin N-terminal |
|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZT18
|
222 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-aMSH | polyclonal | Rabbit |
|
Phoenix Pharmaceuticals, Inc.
|
3 |
Plasmids
No data available