ZFIN ID: ZDB-GENE-030513-2
Gene Name: proopiomelanocortin a
Gene Symbol: pomca

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Previous Names: pomc, ACTH, beta-endorphin, MSH, si:bz36d5.2

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(Including Attributions)
Location: Chr: 17 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 67 figures from 38 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
  adenohypophyseal placode, adenohypophysis, adrenal medulla cell, adrenocorticotropic hormone secreting cell (all 21) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Targeting reagents: MO1-pomca (1)
PHENOTYPE
Data: 2 figures from Wagle et al., 2011
Observed in: melanocyte melanosome, melanosome localization
DISEASE ASSOCIATED WITH pomca HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
obesity {Obesity, early-onset, susceptibility to} 601665
Obesity, adrenal insufficiency, and red hair due to POMC deficiency 609734
GENE ONTOLOGY
Ontology GO Term
Biological Process neuropeptide signaling pathway (more)
Cellular Component extracellular region (more)
Molecular Function neuropeptide hormone activity (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001941 (1)
  • InterPro:IPR013531 (1)
  • InterPro:IPR013532 (1)
  • InterPro:IPR013593 (1)
  • Pfam:PF00976 (1)
  • Pfam:PF08035 (1)
  • Pfam:PF08384 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pomca-001 (1) 1224
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    Ab1-aMSH (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM pomca
    Tg(-1.0pomca:GFP), Tg(Mmu.Pomc-pomca:pomca-EGFP), Tg(pomc:Bal.bPAC-2A-Tomato), Tg(pomca:EGFP-Aequorin), Tg(pomca:pttg1) (all 6) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    pomcaContained in: [BAC] RP71-36D5 (1) (order this)
    pomcaEncodes: [cDNA] MGC:162115 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_181438 (1) 1248bp
    Genomic GenBank:AL590149 (1) 167272bp
    Select Tool
    Polypeptide UniProtKB:Q7ZT18 (1) 222aa
    Sequence Clusters UniGene:19934 (1)
    Sequence Information (all 19)
    OTHER pomca GENE PAGES
  • Gene:353221 (1)
  • VEGA:OTTDARG00000001903 (1)
  • Ensembl(GRCz10):ENSDARG00000043135 (1)
  • ORTHOLOGY for pomca (Chr: 17)
    CITATIONS (89)