ZFIN ID: ZDB-GENE-030513-2
Gene Name: proopiomelanocortin a
Gene Symbol: pomca    Nomenclature History

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Previous Names: pomc, ACTH, beta-endorphin, MSH, si:bz36d5.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Exhibits neuropeptide hormone activity. Involved in several processes, including melanosome localization; multicellular organismal response to stress; and regulation of hematopoietic stem cell differentiation. Predicted to localize to extracellular region. Is expressed in several structures, including adenohypophyseal placode; adrenal medulla cell; diencephalon; endocrine cell; and male organism. Human ortholog(s) of this gene implicated in familial Mediterranean fever; obesity; and osteoarthritis. Orthologous to human POMC (proopiomelanocortin).
Genome Resources: Alliance (1),  Gene:353221 (1),  Ensembl(GRCz11):ENSDARG00000043135 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb408 Small Deletion Unknown Unknown TALEN
ihb409 Insertion Unknown Unknown TALEN
ihb410 Small Deletion Unknown Unknown TALEN
ihb411 Indel Unknown Unknown
ihb412 Insertion Unknown Unknown TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-pomca N/A 3
TALEN1-pomca 1
TALEN2-pomca 1
TALEN3-pomca 1
DISEASE ASSOCIATED WITH pomca HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
obesity Alliance {Obesity, early-onset, susceptibility to} 601665
Obesity, adrenal insufficiency, and red hair due to POMC deficiency 609734
DISEASE ASSOCIATED WITH pomca VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process neuropeptide signaling pathway (more)
Cellular Component extracellular region (more)
Molecular Function neuropeptide hormone activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA pomca-201 (1)    Ensembl 1224
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-aMSH polyclonal Rabbit IHC Phoenix Pharmaceuticals, Inc.
3
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pomca
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-1.0pomca:GAL4-VP16,myl7:EGFP) myl7pomca EGFPGAL4VP16 Danio rerio 1 3
Tg(-1.0pomca:GFP) pomca GFP Danio rerio 2 18
Tg(Mmu.Pomc-pomca:pomca-EGFP) pomca EGFPpomca Danio rerioMus musculus 1 2
Tg(pomc:bPAC-2A-Tomato) pomca bPACTomato Danio rerio 1 4
Tg(pomca:CFP-NTR,myl7:EGFP) myl7pomca CFPEGFPNTR Danio rerio 1 1
Tg(pomca:EGFP-Aequorin) pomca AequorinEGFP Danio rerio 1 1
tg(pomca:egfp-hsa.hras) pomca EGFP Danio rerioHomo sapiens 1 1
Tg(pomca:pttg1) pomca pttg1 Danio rerio 3 3
TgBAC(pomca:KALTA4) pomca KALTA4 Danio rerio 1 1
MARKER RELATIONSHIPS
pomca Contained in: [BAC] RP71-36D5 (1)
pomca Encodes: [cDNA] MGC:162115 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_181438 (1) 1248 nt
Genomic GenBank:AL590149 (1) 167272 nt
Select Tool
Polypeptide UniProtKB:Q7ZT18 (1) 222 aa
Sequence Information (all 17)
ORTHOLOGY for pomca ( Chr: 17 )
CITATIONS (133)