ZFIN ID: ZDB-GENE-030513-1
Gene Name: prolactin
Gene Symbol: prl    Nomenclature History

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Previous Names: prl1 (1), zgc:110500

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have hormone activity. Involved in ion homeostasis; multicellular organismal response to stress; and negative regulation of apoptotic process. Predicted to localize to extracellular space. Is expressed in adenohypophyseal placode; female organism; hypophysis; male organism; and peptide hormone secreting cell. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin).
Genome Resources: Alliance (1),  Gene:791526 (1),  Ensembl(GRCz11):ENSDARG00000037946 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb182 Small Deletion Exon 1 Premature Stop TALEN
ihb183 Small Deletion Exon 1 Premature Stop TALEN
sa6902 Point Mutation Unknown Splice Site ENU
sa26090 Point Mutation Unknown Splice Site ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-prl N/A 2
MO2-prl N/A 2
TALEN1-prl 2
DISEASE ASSOCIATED WITH prl HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH prl VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process ion homeostasis (more)
Cellular Component extracellular region (more)
Molecular Function hormone activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA prl-201 (1)    Ensembl 1399
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM prl
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
TgBAC(prl:RFP) prl RFP Danio rerio 1 10
MARKER RELATIONSHIPS
prl Contained in: [BAC] DKEY-16P21 (1) (order this)
prl Encodes: [cDNA] MGC:110500 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_181437 (1) 1425 nt
Genomic GenBank:BX511021 (1) 235632 nt Blast at MegaBLAST
Polypeptide UniProtKB:F1R0Y2 (1) 210 aa
Sequence Information (all 11)
ORTHOLOGY for prl ( Chr: 3 )
CITATIONS (74)