Gene
yars1
- ID
- ZDB-GENE-030425-2
- Name
- tyrosyl-tRNA synthetase 1
- Symbol
- yars1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have tyrosine-tRNA ligase activity. Involved in cellular response to DNA damage stimulus. Predicted to localize to nucleus. Is expressed in several structures, including hematopoietic system; immature eye; mesoderm; musculature system; and nervous system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb204 (17 images)
- IMAGE:6910575 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Charcot-Marie-Tooth disease dominant intermediate C | Alliance | Charcot-Marie-Tooth disease, dominant intermediate C | 608323 |
Infantile-onset multisystem neurologic, endocrine, and pancreatic disease 2 | 619418 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR002547 | tRNA-binding domain |
Family | IPR002305 | Aminoacyl-tRNA synthetase, class Ic |
Family | IPR002307 | Tyrosine-tRNA ligase |
Family | IPR051270 | Tyrosine-tRNA ligase and regulatory protein |
Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
Domain Details Per Protein
Protein | Length | Aminoacyl-tRNA synthetase, class Ic | Nucleic acid-binding, OB-fold | Rossmann-like alpha/beta/alpha sandwich fold | tRNA-binding domain | Tyrosine-tRNA ligase | Tyrosine-tRNA ligase and regulatory protein |
---|---|---|---|---|---|---|---|
UniProtKB:A0A0R4I9C1
|
529 | ||||||
UniProtKB:Q6TGS6
|
529 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
yars-201
(1)
|
Ensembl | 2,445 nt | ||
mRNA |
yars-202
(1)
|
Ensembl | 898 nt | ||
mRNA |
yars-204
(1)
|
Ensembl | 309 nt | ||
mRNA |
yars-205
(1)
|
Ensembl | 838 nt | ||
mRNA |
yars-206
(1)
|
Ensembl | 753 nt | ||
mRNA |
yars1-208
(1)
|
Ensembl | 2,463 nt | ||
ncRNA |
yars-002
(1)
|
Ensembl | 608 nt | ||
ncRNA |
yars-003
(1)
|
Ensembl | 758 nt |
Interactions and Pathways
No data available
Plasmids
No data available