Gene

yars1

ID
ZDB-GENE-030425-2
Name
tyrosyl-tRNA synthetase 1
Symbol
yars1 Nomenclature History
Previous Names
  • TyrRS (1)
  • yars
  • cb204 (1)
  • wu:fk52b08
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to enable tyrosine-tRNA ligase activity. Acts upstream of or within cellular response to DNA damage stimulus. Predicted to be located in nucleus. Is expressed in several structures, including hematopoietic system; immature eye; mesoderm; musculature system; and nervous system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With yars1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease dominant intermediate C Alliance Charcot-Marie-Tooth disease, dominant intermediate C 608323
Infantile-onset multisystem neurologic, endocrine, and pancreatic disease 2 619418
Associated With yars1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002547 tRNA-binding domain
Family IPR002305 Aminoacyl-tRNA synthetase, class Ic
Family IPR002307 Tyrosine-tRNA ligase
Family IPR023617 Tyrosine-tRNA ligase, archaeal/eukaryotic-type
Homologous_superfamily IPR012340 Nucleic acid-binding, OB-fold
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class Ic Nucleic acid-binding, OB-fold Rossmann-like alpha/beta/alpha sandwich fold tRNA-binding domain Tyrosine-tRNA ligase Tyrosine-tRNA ligase, archaeal/eukaryotic-type
UniProtKB:A0A0R4I9C1 529
UniProtKB:Q1LWM0 87
UniProtKB:Q1LWM3 286
UniProtKB:Q1LWM2 251
UniProtKB:Q6TGS6 529
UniProtKB:A8KBY3 529
UniProtKB:Q1LWM1 228
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations