ZFIN ID: ZDB-GENE-030424-1
Gene Name: lysine (K)-specific demethylase 5Bb
Gene Symbol: kdm5bb    Nomenclature History

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Previous Names: cb264 (1), jarid1bb, plu1, wu:fc44h11, zgc:85741

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have histone demethylase activity (H3-dimethyl-K4 specific) and histone demethylase activity (H3-trimethyl-K4 specific). Predicted to be involved in chromatin remodeling. Predicted to localize to histone methyltransferase complex. Is expressed in several structures, including hindbrain neural plate; musculature system; nervous system; neural tube; and solid lens vesicle. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability; breast cancer; and malignant glioma. Orthologous to human KDM5B (lysine demethylase 5B).
Genome Resources: Alliance (1),  Gene:415256 (1),  Ensembl(GRCz11):ENSDARG00000003098 (2)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH kdm5bb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Mental retardation, autosomal recessive 65 618109
DISEASE ASSOCIATED WITH kdm5bb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process chromatin organization (more)
Cellular Component nucleus (more)
Molecular Function histone demethylase activity (H3-dimethyl-K4 specific) (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA kdm5bb-203 (1)    Ensembl 600
kdm5bb-204 (1)    Ensembl 5138
kdm5bb-205 (1)    Ensembl 1199
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM kdm5bb
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(kdm5bb-hsp70l:EGFP) hsp70lkdm5bb EGFP Danio rerio 1 1
MARKER RELATIONSHIPS
kdm5bb Contained in: [BAC] DKEY-193L3 (1) (order this), DKEYP-53E12 (1)
kdm5bb Encodes: [EST] cb264 (1), fc44h11
[cDNA] MGC:85741 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001002166 (1) 5421 nt
Genomic GenBank:BX664742 (1) 215608 nt Blast at MegaBLAST
Polypeptide UniProtKB:G1K2I1 (1) 1522 aa
Sequence Information (all 27)
ORTHOLOGY for kdm5bb ( Chr: 8 )
CITATIONS (31)