ZFIN Gene: mib1

ZFIN ID: ZDB-GENE-030404-2

ZFIN ID: ZDB-GENE-030404-2

Gene Name:

mindbomb E3 ubiquitin protein ligase 1

Gene Symbol:

mib1 Nomenclature History

Previous Names:

mib, cg5841 (1), chunp6889, fe47f05, im:7148100 (1), KIAA1323 (1), mind bomb, white tail (3), wit (3), wu:fe47f05 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 2 Mapping Details/Browsers

Description:

Exhibits identical protein binding activity and ubiquitin-protein transferase activity. Involved in several processes, including animal organ development; nervous system development; and tube morphogenesis. Localizes to endocytic vesicle; perinuclear region of cytoplasm; and protein-containing complex. Is expressed in nervous system; neural tube; and pectoral fin. Used to study epilepsy. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Orthologous to human MIB1 (mindbomb E3 ubiquitin protein ligase 1).

Genome Resources:

Alliance (1), Gene:352910 (1), Ensembl(GRCz11):ENSDARG00000102184 (1)

GENE EXPRESSION
All Expression Data:	11 figures from 9 publications
Directly Submitted Expression Data:	1 figure (1 image) from Thisse et al., 2004 [IMAGE:7148100]
	1 figure (1 image) from Thisse et al., 2005 [eu763]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
	brain hindbrain mesenchyme pectoral fin neural tube neuron pectoral fin unspecified whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
hi904Tg	Transgenic Insertion	Exon 4	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
m132	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
m178	Point Mutation	Unknown	Premature Stop	ENU
mib1_unspecified	Unspecified	Unknown	Unknown
nn2000	Point Mutation	Unknown	Premature Stop	ENU
nn2001	Insertion	Unknown	Unknown	ENU
sa31118	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa44378	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
ta52b	Point Mutation	Unknown	Missense	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
tfi91	Point Mutation	Unknown	Premature Stop
tfi101	Point Mutation	Unknown	Missense

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-mib1		1
CRISPR2-mib1		1
CRISPR3-mib1		1
MO1-mib1	N/A	10
MO2-mib1	N/A	1
MO3-mib1	N/A	1
MO4-mib1	N/A	2

PHENOTYPE

Data:

126 figures from 74 publications

Observed in:

DISEASE ASSOCIATED WITH mib1 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Left ventricular noncompaction 7	615092

DISEASE ASSOCIATED WITH mib1 VIA EXPERIMENTAL MODELS

Human Disease	Fish	Conditions	Citations
epilepsy	mib1^{hi904Tg/hi904Tg}	standard conditions	Hortopan et al., 2010

GENE ONTOLOGY

Ontology	GO Term
Biological Process	protein autoubiquitination (more)
Cellular Component	cytoplasm (more)
Molecular Function	ubiquitin-protein transferase activity (more)

GO Terms (all 84)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	mib1-201 (1)	4673	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mib1-202 (1)	3227	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mib1-205 (1)	698	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mib1-206 (1)	712	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	mib1-005 (1)	1647	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

SignaFish

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM mib1

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(col2a1a:mib_M1013R)	col2a1a	mib1	Danio rerio	1	2
Tg(hsp70l-mib1:EGFP)	hsp70l, mib1	EGFP	Danio rerio	2	2

MARKER RELATIONSHIPS

mib1 Contained in:	[BAC] DKEY-2P18 (1) (order this) [Fosmid] CH1073-221A23 (1)
mib1 Encodes:	[EST] eu763 (1), fe47f05, IMAGE:7148100 (1) [cDNA] MGC:193576 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_173286 (1)	3293 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX842700 (1)	198258 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:B3DGQ0 (1)	1041 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 39)

ORTHOLOGY for mib1 ( Chr: 2 )

CITATIONS (259)

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