ZFIN Gene: mib1

ZFIN ID: ZDB-GENE-030404-2

ZFIN ID: ZDB-GENE-030404-2

Gene Name:

mindbomb E3 ubiquitin protein ligase 1

Gene Symbol:

mib1

Sequence Ontology ID :

Previous Names:

mib, cg5841 (1), chunp6889, fe47f05, im:7148100 (1), KIAA1323 (1), mind bomb, white tail (3), wit (3), wu:fe47f05 (1)

Location:

Chr: 2 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Exhibits protein homodimerization activity and ubiquitin-protein transferase activity; involved in several processes, including animal organ development, nervous system development, and tube ...

GENE EXPRESSION
All Expression Data:	11 figures from 9 publications
Directly Submitted Expression Data:	1 figure (1 image) from Thisse et al., 2004 [IMAGE:7148100]
	1 figure (1 image) from Thisse et al., 2005 [eu763]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
	brain hindbrain mesenchyme pectoral fin neural tube neuron pectoral fin unspecified whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
hi904Tg	Transgenic Insertion	Exon 4	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
m132	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
m178	Point Mutation	Unknown	Premature Stop	ENU
mib1_unspecified	Unspecified	Unknown	Unknown
nn2000	Point Mutation	Unknown	Premature Stop	ENU
nn2001	Insertion	Unknown	Unknown	ENU
sa31118	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa44378	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
ta52b	Point Mutation	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
tfi91	Point Mutation	Unknown	Premature Stop
tfi101	Point Mutation	Unknown	Missense

Targeting reagents:

PHENOTYPE

Data:

117 figures from 69 publications

Observed in:

DISEASE ASSOCIATED WITH mib1 HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
	Left ventricular noncompaction 7	615092

DISEASE ASSOCIATED WITH mib1 VIA EXPERIMENTAL MODELS

Human Disease	Fish	Conditions	Citations
epilepsy	mib1^{hi904Tg/hi904Tg}	standard conditions	Hortopan et al., 2010

GENE ONTOLOGY

Ontology	GO Term
Biological Process	protein autoubiquitination (more)
Cellular Component	cytoplasm (more)
Molecular Function	protein homodimerization activity (more)

GO Terms (all 85)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000433 (1) InterPro:IPR001841 (1) InterPro:IPR002110 (1) InterPro:IPR010606 (1) InterPro:IPR013083 (1) InterPro:IPR017066 (1) InterPro:IPR020683 (1) InterPro:IPR036770 (1) InterPro:IPR037252 (1) InterPro:IPR040847 (1) InterPro:IPR042056 (1)	PROSITE:PS01357 (1) PROSITE:PS50088 (1) PROSITE:PS50089 (1) PROSITE:PS50135 (1) PROSITE:PS50297 (1) PROSITE:PS51416 (1)	Pfam:PF00569 (1) Pfam:PF06701 (1) Pfam:PF12796 (1) Pfam:PF18346 (1)	EC:2.3.2.27 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
ncRNA	mib1-005 (1)	1647	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	mib1-201 (1)	4673	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mib1-202 (1)	3227	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mib1-205 (1)	698	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mib1-206 (1)	712	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Withdrawn Transcripts
mRNA	mib1-002 (1)	1769	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	mib1-003 (1)	1647	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ottdart00000039413 (1)	1776	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

SignaFish

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM mib1

MARKER RELATIONSHIPS

mib1Contained in:	[BAC] DKEY-2P18 (1) (order this) [Fosmid] CH1073-221A23 (1) (order this)
mib1Encodes:	[EST] eu763 (1), fe47f05, IMAGE:7148100 (1) (order this) [cDNA] MGC:193576 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_173286 (1)	3293bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX842700 (1)	198258bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:B3DGQ0 (1)	1041aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:106501 (1)

Sequence Information (all 42)

OTHER mib1 GENE PAGES

Alliance (1)

Gene:352910 (1)

VEGA:OTTDARG00000019100 (1)

Ensembl(GRCz11):ENSDARG00000102184 (1)

ORTHOLOGY for mib1 (Chr: 2)

CITATIONS (250)

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