Gene
mib1
- ID
- ZDB-GENE-030404-2
- Name
- MIB E3 ubiquitin protein ligase 1
- Symbol
- mib1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables identical protein binding activity. Contributes to ubiquitin-protein transferase activity. Acts upstream of or within several processes, including nervous system development; sensory system development; and tube morphogenesis. Located in endocytic vesicle and perinuclear region of cytoplasm. Part of protein-containing complex. Is expressed in blood vessel; embryonic structure; nervous system; neural tube; and pectoral fin. Used to study epilepsy. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Orthologous to human MIB1 (MIB E3 ubiquitin protein ligase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 143 figures from 85 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Left ventricular noncompaction 7 | 615092 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| epilepsy | mib1hi904Tg/hi904Tg | standard conditions | Hortopan et al., 2010 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000433 | Zinc finger, ZZ-type |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR010606 | Mib-herc2 |
| Domain | IPR040847 | Mind bomb, SH3 repeat domain |
| Domain | IPR042056 | E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Homologous_superfamily | IPR037252 | Mib/herc2 domain superfamily |
| Homologous_superfamily | IPR043145 | Zinc finger, ZZ-type superfamily |
| Repeat | IPR002110 | Ankyrin repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type | Mib-herc2 | Mib/herc2 domain superfamily | Mind bomb, SH3 repeat domain | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, ZZ-type | Zinc finger, ZZ-type superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:H9GYU5 | InterPro | 1041 | ||||||||||
| UniProtKB:A0A8M3AMW2 | InterPro | 1017 | ||||||||||
| UniProtKB:Q804S5 | InterPro | 1030 | ||||||||||
| UniProtKB:A0A8M3AVC7 | InterPro | 1006 | ||||||||||
| UniProtKB:A0A8M3AMW8 | InterPro | 1006 | ||||||||||
| UniProtKB:A0A8M3AYD8 | InterPro | 1030 | ||||||||||
| UniProtKB:A0A8M3ANM1 | InterPro | 1040 | ||||||||||
| UniProtKB:A0AB32U206 | InterPro | 1029 |
Interactions and Pathways
Plasmids
No data available