header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030404-2
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.
Gene Name: mindbomb E3 ubiquitin protein ligase 1
Gene Symbol: mib1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: mib, cg5841 (1), chunp6889, fe47f05, im:7148100 (1), KIAA1323 (1), mind bomb, white tail (3), wit (3), wu:fe47f05 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Exhibits protein homodimerization activity and ubiquitin-protein transferase activity. Involved in several processes, including animal organ development; nervous system development; and tube morphogenesis. Localizes to the endocytic vesicle; perinuclear region of cytoplasm; and protein-containing complex. Used to study epilepsy. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Is expressed in nervous system; neural tube; and pectoral fin. Orthologous to human MIB1 (mindbomb E3 ubiquitin protein ligase 1).
Genome Resources: Alliance (1), Gene:352910 (1), Ensembl(GRCz11):ENSDARG00000102184 (1)
GENE EXPRESSION
All Expression Data: 11 figures from 9 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7148100]
  1 figure (1 image) from Thisse et al., 2005 [eu763]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi904Tg Transgenic Insertion Exon 4 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • m132 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • m178 Point Mutation Unknown Premature Stop ENU
    mib1_unspecified Unspecified Unknown Unknown
    nn2000 Point Mutation Unknown Premature Stop ENU
    nn2001 Insertion Unknown Unknown ENU
    sa31118 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa44378 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • ta52b Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • tfi91 Point Mutation Unknown Premature Stop
    tfi101 Point Mutation Unknown Missense
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mib1
    		1
    CRISPR2-mib1
    		1
    CRISPR3-mib1
    		1
    MO1-mib1 N/A 10
    MO2-mib1 N/A 1
    MO3-mib1 N/A 1
    MO4-mib1 N/A 2
    PHENOTYPE
    Data: 123 figures from 72 publications
    Observed in:
    DISEASE ASSOCIATED WITH mib1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Left ventricular noncompaction 7 615092
    DISEASE ASSOCIATED WITH mib1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    epilepsy mib1hi904Tg/hi904Tg standard conditions Hortopan et al., 2010
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein autoubiquitination (more)
    Cellular Component cytoplasm (more)
    Molecular Function ubiquitin-protein transferase activity (more)
    GO Terms (all 85)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000433 (1)
  • InterPro:IPR001841 (1)
  • InterPro:IPR002110 (1)
  • InterPro:IPR010606 (1)
  • InterPro:IPR013083 (1)
  • InterPro:IPR017066 (1)
  • InterPro:IPR020683 (1)
  • InterPro:IPR036770 (1)
  • InterPro:IPR037252 (1)
  • InterPro:IPR040847 (1)
  • InterPro:IPR042056 (1)
    		•
  • PROSITE:PS01357 (1)
  • PROSITE:PS50088 (1)
  • PROSITE:PS50089 (1)
  • PROSITE:PS50135 (1)
  • PROSITE:PS50297 (1)
  • PROSITE:PS51416 (1)
    		•
  • Pfam:PF00569 (1)
  • Pfam:PF06701 (1)
  • Pfam:PF12796 (1)
  • Pfam:PF18346 (1)
    		•
  • EC:2.3.2.27 (1)
    		•
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mib1-201 (1)    Ensembl 4673
    Select Tool
    mib1-202 (1)    Ensembl 3227
    Select Tool
    mib1-205 (1)    Ensembl 698
    Select Tool
    mib1-206 (1)    Ensembl 712
    Select Tool
    ncRNA mib1-005 (1)    Ensembl 1647
    Select Tool
    Browsers: UCSC, NCBI, Ensembl, ZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM mib1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(col2a1a:mib_M1013R) col2a1a mib1 Danio rerio 1 2
    Tg(hsp70l-mib1:EGFP) hsp70l, mib1 EGFP Danio rerio 2 2
    MARKER RELATIONSHIPS
    mib1Contained in: [BAC] DKEY-2P18 (1) (order this)
    [Fosmid] CH1073-221A23 (1) (order this)
    mib1Encodes: [EST] eu763 (1), fe47f05, IMAGE:7148100 (1) (order this)
    [cDNA] MGC:193576 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_173286 (1) 3293bp
    Select Tool
    Genomic GenBank:BX842700 (1) 198258bp
    Select Tool
    Polypeptide UniProtKB:B3DGQ0 (1) 1041aa
    Select Tool
    Sequence Clusters UniGene:106501 (1)
    Sequence Information (all 41)
    ORTHOLOGY for mib1 (Chr: 2)
    CITATIONS (253)