ZFIN ID: ZDB-GENE-030326-5
Gene Name: aldehyde dehydrogenase 2 family member, tandem duplicate 2
Gene Symbol: aldh2.2    Nomenclature History

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Previous Names: aldh2, aldh2b, aldh2l, cb154 (1), wu:fi26c02, zgc:85659

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have aldehyde dehydrogenase (NAD+) activity. Involved in regulation of cellular response to drug. Is expressed in several structures, including digestive system; fin; immature eye; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member).
Genome Resources: Alliance (1),  Gene:368239 (1),  Ensembl(GRCz11):ENSDARG00000028087 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-aldh2.2 N/A 1
MO2-aldh2.2 N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH aldh2.2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Alcohol sensitivity, acute 610251
{Esophageal cancer, alcohol-related, susceptibility to}
{Hangover, susceptibility to} 610251
{Sublingual nitroglycerin, susceptibility to poor response to}
DISEASE ASSOCIATED WITH aldh2.2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of cellular response to drug (more)
Molecular Function oxidoreductase activity (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
Browsers: NCBI
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM aldh2.2 No data available
MARKER RELATIONSHIPS
aldh2.2 Contained in: [BAC] CH211-157P22 (1), DKEY-204G14 (1) (order this)
aldh2.2 Encodes: [EST] cb154 (1) (order this), fi26c02 (1)
[cDNA] MGC:85659 (1), MGC:136498 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_213301 (1) 2002 nt
Genomic GenBank:CT978957 (1) 164556 nt
Select Tool
Polypeptide UniProtKB:F1QZU7 (1) 516 aa
Sequence Information (all 25)
ORTHOLOGY for aldh2.2 ( Chr: 5 )
CITATIONS (33)