ZFIN ID: ZDB-GENE-030326-1
Gene Name: dihydrolipoamide S-succinyltransferase
Gene Symbol: dlst    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: cb60 (1), schneckentempo (1), wu:fc39d01

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have dihydrolipoyllysine-residue succinyltransferase activity. Involved in several processes, including ATP biosynthetic process; heart contraction; and mitochondrion morphogenesis. Predicted to localize to oxoglutarate dehydrogenase complex. Is expressed in several structures, including immature eye; musculature system; nervous system; neural plate; and segmental plate. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase).
Genome Resources: Alliance (1),  Gene:368262 (1),  Ensembl(GRCz11):ENSDARG00000014230 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi1903cTg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la027887Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17039 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t21498 Point Mutation Donor Splice Site of Intron 5 Splice Site, Frameshift, Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dlst N/A 1
    MO2-dlst N/A 1
    DISEASE ASSOCIATED WITH dlst HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Paragangliomas 7 618475
    DISEASE ASSOCIATED WITH dlst VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ATP biosynthetic process (more)
    Cellular Component oxoglutarate dehydrogenase complex (more)
    Molecular Function dihydrolipoyllysine-residue succinyltransferase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dlst-201 (1)    Ensembl 1889
    ncRNA dlst-002 (1)    Ensembl 725
    dlst-003 (1)    Ensembl 764
    dlst-004 (1)    Ensembl 706
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dlst No data available
    MARKER RELATIONSHIPS
    dlst Contained in: [BAC] CH211-173A9 (1)
    dlst Contains: [SNP] rs3728885, rs3728886, rs3728887
    dlst Encodes: [EST] cb60 (1) (order this), fc39d01 (1)
    [cDNA] MGC:55935 (1), MGC:77238 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201487 (1) 1898 nt
    Genomic GenBank:AL935141 (1) 136178 nt
    Select Tool
    Polypeptide UniProtKB:F1QFQ6 (1) 458 aa
    Sequence Information (all 17)
    ORTHOLOGY for dlst ( Chr: 17 )
    CITATIONS (35)