ZFIN ID: ZDB-GENE-030325-1
Gene Name: protein kinase, AMP-activated, alpha 1 catalytic subunit
Gene Symbol: prkaa1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: ampka1 (1), cb116 (1), im:7154392, sb:cb130, wu:fa94c10

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Involved in negative regulation of hh target transcription factor activity. Predicted to localize to the cytoplasm; nucleotide-activated protein kinase complex; and nucleus. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; and colon cancer. Is expressed in several structures, including axis; digestive system; margin; mesoderm; and nervous system. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1).
Genome Resources: Alliance (1),  Gene:100001198 (1),  Ensembl(GRCz11):ENSDARG00000060596 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-prkaa1 N/A 1
MO2-prkaa1 N/A 1
DISEASE ASSOCIATED WITH prkaa1 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH prkaa1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of hh target transcription factor activity (more)
Cellular Component cytoplasm (more)
Molecular Function AMP-activated protein kinase activity (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR032270 AMPK, C-terminal adenylate sensor domain
Domain IPR039137 5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminal
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR028375 KA1 domain/Ssp2, C-terminal
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA prkaa1-201 (1)    Ensembl 3939
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM prkaa1 No data available
MARKER RELATIONSHIPS
prkaa1 Contained in: [BAC] CH73-278C20 (1), DKEY-226M8 (1) (order this)
prkaa1 Encodes: [EST] cb116 (1) (order this), cb130 (1) (order this), fa94c10, IMAGE:7154392 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001110286 (1) 1939 nt
Genomic GenBank:CR382323 143411 nt
Select Tool
Polypeptide UniProtKB:A5WUM0 (1) 573 aa
Sequence Information (all 14)
ORTHOLOGY for prkaa1 ( Chr: 5 )
CITATIONS (33)