Gene

p2rx7

ID
ZDB-GENE-030319-6
Name
purinergic receptor P2X, ligand-gated ion channel, 7
Symbol
p2rx7 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Exhibits extracellularly ATP-gated cation channel activity. Involved in calcium ion import across plasma membrane and macrophage chemotaxis. Localizes to plasma membrane. Is expressed in brain; midbrain hindbrain boundary; pronephric duct; and spinal cord. Orthologous to human P2RX7 (purinergic receptor P2X 7).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. S2 from Ogryzko et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With p2rx7 Human Ortholog
No data available
Associated With p2rx7 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001429 P2X purinoreceptor
Family IPR003050 P2X7 purinoceptor
Homologous_superfamily IPR027309 P2X purinoreceptor extracellular domain superfamily
Domain Details Per Protein
Protein Length P2X7 purinoceptor P2X purinoreceptor P2X purinoreceptor extracellular domain superfamily
UniProtKB:B3DIB7 596
UniProtKB:F1QJ17 596
UniProtKB:A0A2R8QGJ4 597
UniProtKB:Q7SZM2 596
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-p2rx7 polyclonal Rabbit
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations