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ZIRC
ZFIN ID: ZDB-GENE-030318-2
Gene Name: CHM Rab escort protein
Gene Symbol: chm    Nomenclature History

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Previous Names: eva, evanescence (1), REP1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Exhibits Rab geranylgeranyltransferase activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of sound; iridophore differentiation; and sensory organ development. Predicted to localize to the Rab-protein geranylgeranyltransferase complex; cytosol; and nucleus. Used to study choroideremia. Human ortholog(s) of this gene implicated in asthma and choroideremia. Orthologous to several human genes including CHM (CHM Rab escort protein).
Genome Resources: Alliance (1),  Gene:402935 (1),  Ensembl(GRCz11):ENSDARG00000003845 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:109728]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 6 (144.0h-168.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011418Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • rk10 Point Mutation Exon 12 Splice Site, Premature Stop
    ru848 Point Mutation Exon 2 Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6679 Point Mutation Unknown Splice Site ENU
    sa23994 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-chm N/A 1
    DISEASE ASSOCIATED WITH chm HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    choroideremia Alliance Choroideremia 303100
    DISEASE ASSOCIATED WITH chm VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    choroideremia chmru848/ru848 standard conditions (4)
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process detection of mechanical stimulus involved in sensory perception of sound (more)
    Cellular Component cytoplasm (more)
    Molecular Function Rab geranylgeranyltransferase activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001738 (1)
  • InterPro:IPR018203 (1)
  • InterPro:IPR036188 (1)
  • Pfam:PF00996 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA chm-201 (1)    Ensembl 2559
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-chm polyclonal WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM chm No data available
    MARKER RELATIONSHIPS
    chm Contained in: [BAC] CH211-112H5 (1) (order this), CH211-182D6 (1) (order this), CH211-268H1 (1) (order this)
    chm Encodes: [cDNA] MGC:109728 (1) (order this), MGC:173910 (1) (order this), MGC:191736 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_203461 (1) 2528 bp
    Genomic RefSeq:NW_018395095 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:A8KBQ8 (1) 666 aa
    Sequence Clusters UniGene:133306 (1)
    Sequence Information (all 28)
    ORTHOLOGY for chm ( Chr: 21 )
    CITATIONS (38)