Gene

epha2b

ID

ZDB-GENE-030219-187

Name

eph receptor A2 b

Symbol

epha2b Nomenclature History

Previous Names

id:ibd2608

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have ATP binding activity and ephrin receptor activity. Predicted to be involved in protein phosphorylation and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in cataract 6 multiple types. Is expressed in shield and somite. Orthologous to human EPHA2 (EPH receptor A2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from Kudoh et al., 2001

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Harding et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With epha2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cataract 6 multiple types	Alliance	Cataract 6, multiple types	116600

Associated With epha2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001090	Ephrin receptor ligand binding domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR001660	Sterile alpha motif domain
Domain	IPR003961	Fibronectin type III
Domain	IPR011641	Tyrosine-protein kinase ephrin type A/B receptor-like
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR027936	Ephrin receptor, transmembrane domain
Family	IPR016257	Ephrin receptor type-A /type-B
Family	IPR050449	Ephrin receptor tyrosine kinases
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily

Domain Details Per Protein

Protein	Length	Ephrin receptor ligand binding domain	Ephrin receptor, transmembrane domain	Ephrin receptor type-A /type-B	Ephrin receptor tyrosine kinases	Fibronectin type III	Fibronectin type III superfamily	Galactose-binding-like domain superfamily	Growth factor receptor cysteine-rich domain superfamily	Immunoglobulin-like fold	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain	Sterile alpha motif domain	Sterile alpha motif/pointed domain superfamily	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase ephrin type A/B receptor-like
UniProtKB:E7F533 InterPro	979
UniProtKB:A0A8M9PWZ3 InterPro	331

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	epha2b-201 (1) Ensembl	Ensembl		2,940 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations