Gene

hells

ID
ZDB-GENE-030131-9923
Name
helicase, lymphoid specific
Symbol
hells Nomenclature History
Previous Names
  • cb65 (1)
  • im:6911667
  • sb:cb65
  • sb:cb749
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have DNA binding activity and DNA-dependent ATPase activity. Involved in regulation of DNA methylation. Predicted to localize to nucleus. Is expressed in several structures, including alar plate midbrain region; central nervous system; immature eye; margin; and pectoral fin musculature. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific).
Genome Resources
Note
None
Expression
All Expression Data
19 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Dunican et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hells Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency-centromeric instability-facial anomalies syndrome 4 Alliance Immunodeficiency-centromeric instability-facial anomalies syndrome 4 616911
Associated With hells Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000330 SNF2-related domain
Domain IPR001650 Helicase, C-terminal
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR038718 SNF2-like, N-terminal domain superfamily
Domain Details Per Protein
Protein Length Helicase, C-terminal Helicase superfamily 1/2, ATP-binding domain P-loop containing nucleoside triphosphate hydrolase SNF2-like, N-terminal domain superfamily SNF2-related domain
UniProtKB:Q3BDS6 853
UniProtKB:Q5BLD7 252
UniProtKB:A0A2R8Q4P5 838
UniProtKB:B7ZD98 853
UniProtKB:Q08CT9 769
UniProtKB:A4FVH1 270
UniProtKB:A8WFW2 290
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations