ZFIN ID: ZDB-GENE-030131-9884
Gene Name: coproporphyrinogen oxidase
Gene Symbol: cpox    Nomenclature History

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Previous Names: cpo (1), cb535 (1), im:7156501, sb:cb535, wu:fc43a01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have coproporphyrinogen oxidase activity. Involved in hemoglobin biosynthetic process. Predicted to localize to mitochondrial intermembrane space. Is expressed in hematopoietic system; mesoderm; presumptive blood; and ventral mesenchyme. Human ortholog(s) of this gene implicated in hereditary coproporphyria and liver disease. Orthologous to human CPOX (coproporphyrinogen oxidase).
Genome Resources: Alliance (1),  Gene:321294 (1),  Ensembl(GRCz11):ENSDARG00000062025 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026378Tg Transgenic Insertion Unknown Unknown DNA
sa6095 Point Mutation Unknown Splice Site ENU
sa21253 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sus004 Small Deletion Unknown Unknown CRISPR
    sus005 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cpox 2
    MO1-cpox N/A 1
    MO2-cpox N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cpox HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary coproporphyria Alliance Coproporphyria 121300
    Harderoporphyria 618892
    DISEASE ASSOCIATED WITH cpox VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hemoglobin biosynthetic process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function coproporphyrinogen oxidase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cpox No data available
    MARKER RELATIONSHIPS
    cpox Contained in: [BAC] CH211-232D19 (1)
    cpox Encodes: [EST] cb535 (1) (order this), fc43a01 (1) (order this), IMAGE:7156501 (1)
    [cDNA] MGC:153806 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001040094 (1) 1970 nt
    Genomic GenBank:BX247907 169530 nt
    Select Tool
    Polypeptide UniProtKB:Q05AK3 (1) 449 aa
    Sequence Information (all 18)
    ORTHOLOGY for cpox ( Chr: 8 )
    CITATIONS (39)