Gene

lama5

ID

ZDB-GENE-030131-9823

Name

laminin, alpha 5

Symbol

lama5 Nomenclature History

Previous Names

fra (1)
cb402 (1)
fransen (1)
im:7138247
sb:cb402
unm m538
wu:fb81a10

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to enable integrin binding activity. Acts upstream of or within cell-cell adhesion; fin morphogenesis; and protein localization. Predicted to be located in extracellular region and membrane. Predicted to be part of laminin-5 complex. Predicted to be active in basement membrane. Is expressed in several structures, including axial mesoderm; endoderm; nervous system; pectoral fin bud; and pharynx. Human ortholog(s) of this gene implicated in familial nephrotic syndrome. Orthologous to human LAMA5 (laminin subunit alpha 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

32 figures from 11 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb402 (39 images)
IMAGE:7138247 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 18 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lama5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Nephrotic syndrome, type 26	620049
		?Bent bone dysplasia syndrome 2	620076

Associated With lama5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000034	Laminin IV
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR002049	Laminin-type EGF domain
Domain	IPR008211	Laminin, N-terminal
Domain	IPR009254	Laminin alpha, domain I
Domain	IPR010307	Laminin domain II
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily