ZFIN ID: ZDB-GENE-030131-9790
Gene Name: ATP-binding cassette, sub-family A (ABC1), member 12
Gene Symbol: abca12    Nomenclature History

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Previous Names: cb352 (1), sb:cb352

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have ATPase-coupled transmembrane transporter activity; apolipoprotein A-I receptor binding activity; and lipid transporter activity. Involved in epidermis morphogenesis. Predicted to localize to intracellular membrane-bounded organelle. Is expressed in EVL; ectoderm; integument; peripheral olfactory organ; and pharynx. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1; autosomal recessive congenital ichthyosis 4A; and autosomal recessive congenital ichthyosis 4B. Orthologous to human ABCA12 (ATP binding cassette subfamily A member 12).
Genome Resources: Alliance (1),  Gene:558335 (1),  Ensembl(GRCz11):ENSDARG00000074749 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2001 [cb352]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026982Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2502 Point Mutation Unknown Premature Stop ENU
    sa9840 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18961 Point Mutation Unknown Premature Stop ENU
    sa34715 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41498 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-abca12 N/A 1
    DISEASE ASSOCIATED WITH abca12 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive congenital ichthyosis 4A Alliance Ichthyosis, congenital, autosomal recessive 4A 601277
    autosomal recessive congenital ichthyosis 4B Alliance Ichthyosis, congenital, autosomal recessive 4B (harlequin) 242500
    DISEASE ASSOCIATED WITH abca12 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process epidermis morphogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATPase activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA abca12-201 (1)    Ensembl 6192
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM abca12 No data available
    MARKER RELATIONSHIPS
    abca12 Contained in: [BAC] CH211-207D8 (1), DKEY-124M15 (1) (order this)
    abca12 Encodes: [EST] cb352 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_681540 (1) 18816 nt
    Genomic GenBank:CR753890 (1) 201771 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1QLU8 (1) 1809 aa
    Sequence Information (all 17)
    ORTHOLOGY for abca12 ( Chr: 9 )
    CITATIONS (29)