ZFIN ID: ZDB-GENE-030131-9784
Gene Name: adaptor related protein complex 2 subunit mu 1a
Gene Symbol: ap2m1a    Nomenclature History

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Previous Names: cb34 (1), sb:cb34, wu:fa97a10, zgc:85653 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have clathrin adaptor activity. Involved in Wnt signaling pathway. Predicted to localize to AP-2 adaptor complex and intracellular membrane-bounded organelle. Is expressed in blood; mesoderm; notochord; sensory system; and solid lens vesicle. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1).
Genome Resources: Alliance (1),  Gene:321051 (1),  Ensembl(GRCz11):ENSDARG00000002790 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13901 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32848 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ap2m1a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ap2m1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Intellectual developmental disorder 60 with seizures 618587
    DISEASE ASSOCIATED WITH ap2m1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process Wnt signaling pathway (more)
    Cellular Component clathrin adaptor complex (more)
    Molecular Function lipid binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ap2m1a-202 (1)    Ensembl 2187
    ap2m1a-205 (1)    Ensembl 662
    ap2m1a-206 (1)    Ensembl 519
    ncRNA ap2m1a-003 (1)    Ensembl 199
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ap2m1a No data available
    MARKER RELATIONSHIPS
    ap2m1a Contained in: [BAC] CH211-252F13 (1)
    ap2m1a Contains: [STS] chunp30556
    ap2m1a Encodes: [EST] cb34 (1) (order this), fa97a10 (1), IMAGE:7161024 (1)
    [cDNA] MGC:55711 (1), MGC:85653 (1), MGC:191385 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212577 (1) 2045 nt
    Genomic GenBank:BX470264 (1) 168673 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IL09 (1) 441 aa
    Sequence Information (all 33)
    ORTHOLOGY for ap2m1a ( Chr: 2 )
    CITATIONS (28)