Gene

paics

ID
ZDB-GENE-030131-9762
Name
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
Symbol
paics Nomenclature History
Previous Names
  • cb293 (1)
  • multifunctional protein ADE2 (1)
  • sb:cb293
  • wu:fa28a05
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable ATP binding activity; carboxy-lyase activity; and phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Acts upstream of or within chordate embryonic development; pigmentation; and retina development in camera-type eye. Predicted to be active in cytosol. Is expressed in several structures, including eye; immature eye; midbrain; neural tube; and yolk syncytial layer. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With paics Human Ortholog
No data available
Associated With paics Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018236 SAICAR synthetase, conserved site
Domain IPR000031 PurE domain
Domain IPR028923 SAICAR synthetase/ADE2, N-terminal
Domain IPR033626 Class II PurE
Homologous_superfamily IPR035893 PurE domain superfamily
Domain Details Per Protein
Protein Length Class II PurE PurE domain PurE domain superfamily SAICAR synthetase/ADE2, N-terminal SAICAR synthetase, conserved site
UniProtKB:A0A0A0MPG9 1042
UniProtKB:Q7ZUN6 425
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations