ZFIN ID: ZDB-GENE-030131-9762
Gene Name: phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
Gene Symbol: paics    Nomenclature History

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Previous Names: cb293 (1), multifunctional protein ADE2 (1), sb:cb293, wu:fa28a05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Involved in chordate embryonic development; pigmentation; and retina development in camera-type eye. Predicted to localize to cytosol. Is expressed in several structures, including eye; immature eye; midbrain; neural tube; and yolk syncytial layer. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase).
Genome Resources: Alliance (1),  Gene:321193 (1),  Ensembl(GRCz11):ENSDARG00000033539 (2)
GENE EXPRESSION
All Expression Data: 15 figures from 4 publications
Directly Submitted Expression Data: 6 figures (9 images) from Thisse et al., 2001 [cb293]
  6 figures (14 images) from Thisse et al., 2004 [IMAGE:7145230]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Day 6 (144.0h-168.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi2688Tg Transgenic Insertion 5' UTR Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa892 Point Mutation Unknown Splice Site ENU
    sa4900 Point Mutation Unknown Premature Stop ENU
    DISEASE ASSOCIATED WITH paics HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH paics VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process camera-type eye development (more)
    Cellular Component cytosol (more)
    Molecular Function phosphoribosylaminoimidazolesuccinocarboxamide synthase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA paics-201 (1)    Ensembl 3362
    paics-202 (1)    Ensembl 1565
    paics-203 (1)    Ensembl 1720
    paics-204 (1)    Ensembl 1923
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM paics No data available
    MARKER RELATIONSHIPS
    paics Contained in: [BAC] DKEYP-117H8 (1)
    paics Encodes: [EST] cb293 (1) (order this), fa28a05 (1), IMAGE:7145230 (1)
    [cDNA] MGC:55576 (1), MGC:86906 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199537 (1) 1624 nt
    Genomic GenBank:CR352243 (1) 121253 nt
    Select Tool
    Polypeptide UniProtKB:A0A0A0MPG9 (1) 1042 aa
    Sequence Information (all 15)
    ORTHOLOGY for paics ( Chr: 20 )
    CITATIONS (37)