Gene

ftcd

ID
ZDB-GENE-030131-9643
Name
formimidoyltransferase cyclodeaminase
Symbol
ftcd Nomenclature History
Previous Names
  • wu:fp37b11
  • zgc:63647
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have folic acid binding activity and transferase activity. Predicted to be involved in cellular metabolic process. Localizes to Golgi apparatus. Human ortholog(s) of this gene implicated in glutamate formiminotransferase deficiency. Is expressed in liver; pronephric duct; and yolk syncytial layer. Orthologous to human FTCD (formimidoyltransferase cyclodeaminase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ftcd Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
glutamate formiminotransferase deficiency Alliance Glutamate formiminotransferase deficiency 229100
Associated With ftcd Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004227 Formiminotransferase catalytic domain
Domain IPR007044 Cyclodeaminase/cyclohydrolase
Domain IPR012886 Formiminotransferase, N-terminal subdomain
Domain IPR013802 Formiminotransferase, C-terminal subdomain
Homologous_superfamily IPR022384 Formiminotransferase catalytic domain superfamily
Homologous_superfamily IPR036178 Formimidoyltransferase-cyclodeaminase-like superfamily
Homologous_superfamily IPR037064 Formiminotransferase, N-terminal subdomain superfamily
Homologous_superfamily IPR037070 Formiminotransferase, C-terminal subdomain superfamily
Domain Details Per Protein
Protein Length Cyclodeaminase/cyclohydrolase Formimidoyltransferase-cyclodeaminase-like superfamily Formiminotransferase catalytic domain Formiminotransferase catalytic domain superfamily Formiminotransferase, C-terminal subdomain Formiminotransferase, C-terminal subdomain superfamily Formiminotransferase, N-terminal subdomain Formiminotransferase, N-terminal subdomain superfamily
UniProtKB:A0A8M1PIL2
InterPro
540
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA ftcd-201 (1)
Ensembl
Havana 1707 nt
ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ftcd monoclonal IgG1 Mouse
Abcam plc
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.