ZFIN ID: ZDB-GENE-030131-955
Gene Name: eukaryotic translation initiation factor 2B, subunit 4 delta
Gene Symbol: eif2b4    Nomenclature History

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Previous Names: si:ch211-101l18.4, wu:fb54a09 (1), zgc:110790

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have translation initiation factor activity. Predicted to be involved in translational initiation. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta).
Genome Resources: Alliance (1),  Gene:541548 (1),  Ensembl(GRCz11):ENSDARG00000014004 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:110790]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17367 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH eif2b4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    leukoencephalopathy with vanishing white matter Alliance Leukoencephalopathy with vanishing white matter 603896
    Ovarioleukodystrophy 603896
    DISEASE ASSOCIATED WITH eif2b4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular metabolic process (more)
    Molecular Function translation initiation factor activity (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA eif2b4-201 (1)    Ensembl 2120
    eif2b4-203 (1)    Ensembl 578
    ncRNA eif2b4-002 (1)    Ensembl 794
    eif2b4-004 (1)    Ensembl 639
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eif2b4 No data available
    MARKER RELATIONSHIPS
    eif2b4 Contained in: [BAC] CH211-101L18
    eif2b4 Contains: [SNP] rs3729021 (1), rs3729022 (1)
    eif2b4 Encodes: [EST] fb54a09, wz1304
    [cDNA] MGC:110790 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001014361 (1) 2150 nt
    Genomic GenBank:BX276101 (1) 167149 nt
    Select Tool
    Polypeptide UniProtKB:A0A286Y8J6 (1) 554 aa
    Sequence Information (all 21)
    ORTHOLOGY for eif2b4 ( Chr: 20 )
    CITATIONS (24)