ZFIN ID: ZDB-GENE-030131-947
Gene Name: betaine-homocysteine methyltransferase
Gene Symbol: bhmt    Nomenclature History

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Previous Names: hm:zehn2153, wu:fb53h01, wu:fb63c08, wu:fj64d01, zgc:123027

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have betaine-homocysteine S-methyltransferase activity. Involved in digestive system development and type B pancreatic cell development. Predicted to localize to cytoplasm. Is expressed in hepatocyte; liver; yolk; and yolk syncytial layer. Orthologous to several human genes including BHMT (betaine--homocysteine S-methyltransferase).
Genome Resources: Alliance (1),  Gene:322228 (1),  Ensembl(GRCz11):ENSDARG00000013430 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 5 publications
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17114 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bhmt N/A 1
    MO2-bhmt N/A 1
    MO3-bhmt N/A 1
    DISEASE ASSOCIATED WITH bhmt HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH bhmt VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process digestive system development (more)
    Cellular Component cytoplasm (more)
    Molecular Function betaine-homocysteine S-methyltransferase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-bhmt monoclonal Mouse IHC 5
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bhmt
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(bhmt:egfp) bhmt EGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    bhmt Contains: [SNP] rs3729060 (1)
    bhmt Encodes: [EST] fb53h01, fb63c08 (1), fj64d01 (1), zehn2153 (1)
    [cDNA] MGC:123027 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001012480 (1)
    Polypeptide UniProtKB:F1QU55 (1) 400 aa
    Sequence Information (all 20)
    ORTHOLOGY for bhmt ( Chr: 21 )
    CITATIONS (47)