ZFIN ID: ZDB-GENE-030131-9444
Gene Name: peptidase D
Gene Symbol: pepd    Nomenclature History

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Previous Names: cb1000 (1), fj78g11, wu:fj78g11 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have aminopeptidase activity and manganese ion binding activity. Involved in endocrine pancreas development and pancreas regeneration. Is expressed in blood vessel; eye; neural crest; optic vesicle; and yolk syncytial layer. Human ortholog(s) of this gene implicated in prolidase deficiency. Orthologous to human PEPD (peptidase D).
Genome Resources: Alliance (1),  Gene:337498 (1),  Ensembl(GRCz11):ENSDARG00000102249 (1)
GENE EXPRESSION
All Expression Data: 5 figures from 3 publications
Directly Submitted Expression Data: 3 figures (9 images) from Thisse et al., 2001 [cb1000]
  1 figure (1 image) from Thisse et al., 2005 [eu591]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9779 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pepd N/A 1
    DISEASE ASSOCIATED WITH pepd HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    prolidase deficiency Alliance Prolidase deficiency 170100
    DISEASE ASSOCIATED WITH pepd VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endocrine pancreas development (more)
    Cellular Component cellular_component (more)
    Molecular Function aminopeptidase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pepd No data available
    MARKER RELATIONSHIPS
    pepd Encodes: [EST] cb1000 (1) (order this), eu591 (1), fj78g11
    [cDNA] MGC:63814 (1), MGC:174514 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_198912 (1)
    Genomic GenBank:CABZ01068845 (1) 37640 nt
    Select Tool
    Polypeptide UniProtKB:A0A0G2KZA4 (1) 498 aa
    Sequence Information (all 32)
    ORTHOLOGY for pepd ( Chr: 18 )
    CITATIONS (23)