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ZIRC
ZFIN ID: ZDB-GENE-030131-9322
Gene Name: arachidonate 5-lipoxygenase-activating protein
Gene Symbol: alox5ap    Nomenclature History

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Previous Names: Flap (1), wu:fj65d02, zgc:63982

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Involved in angiogenesis. Predicted to localize to the endoplasmic reticulum and nuclear envelope. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma; brain infarction (multiple); breast cancer; and cerebral palsy. Orthologous to human ALOX5AP (arachidonate 5-lipoxygenase activating protein).
Genome Resources: Alliance (1),  Gene:337376 (1),  Ensembl(GRCz11):ENSDARG00000054755 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa41707 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-alox5ap
    1
    MO1-alox5ap N/A 1
    MO2-alox5ap N/A 1
    DISEASE ASSOCIATED WITH alox5ap HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cerebral infarction Alliance {Stroke, susceptibility to} 601367
    DISEASE ASSOCIATED WITH alox5ap VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function enzyme activator activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001129 (1)
  • InterPro:IPR001446 (1)
  • InterPro:IPR023352 (1)
  • Pfam:PF01124 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA alox5ap-201 (1)    Ensembl 1304
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM alox5ap No data available
    MARKER RELATIONSHIPS
    alox5ap Contained in: [BAC] CH211-135J7 (1) (order this)
    alox5ap Encodes: [EST] fj65d02
    [cDNA] MGC:63982 (1) (order this), MGC:192084 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200061 (1) 1327 bp
    Genomic GenBank:BX548163 (1) 132400 bp
    Select Tool
    Polypeptide UniProtKB:F1QKS8 (1) 156 aa
    Sequence Clusters UniGene:48970 (1)
    Sequence Information (all 16)
    ORTHOLOGY for alox5ap ( Chr: 10 )
    CITATIONS (24)