ZFIN ID: ZDB-GENE-030131-9192
Gene Name: aldehyde dehydrogenase 6 family, member A1
Gene Symbol: aldh6a1    Nomenclature History

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Previous Names: cb850 (1), mitochondrial acylating methylmalonate-semialdehyde dehydrogenase, wu:fb03a04, zgc:92082

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have malonate-semialdehyde dehydrogenase (acetylating) activity and methylmalonate-semialdehyde dehydrogenase (acylating) activity. Predicted to be involved in thymine catabolic process and valine catabolic process. Predicted to localize to the mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; midbrain; musculature system; and ventricular zone. Orthologous to human ALDH6A1 (aldehyde dehydrogenase 6 family member A1).
Genome Resources: Alliance (1),  Gene:436647 (1),  Ensembl(GRCz11):ENSDARG00000053485 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa36509 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-aldh6a1 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH aldh6a1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Methylmalonate semialdehyde dehydrogenase deficiency 614105
    DISEASE ASSOCIATED WITH aldh6a1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component mitochondrion (more)
    Molecular Function methylmalonate-semialdehyde dehydrogenase (acylating) activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR010061 Methylmalonate-semialdehyde dehydrogenase
    Domain IPR015590 Aldehyde dehydrogenase domain
    Conserved_site IPR016160 Aldehyde dehydrogenase, cysteine active site
    Homologous_superfamily IPR016161 Aldehyde/histidinol dehydrogenase
    Homologous_superfamily IPR016162 Aldehyde dehydrogenase, N-terminal
    Homologous_superfamily IPR016163 Aldehyde dehydrogenase, C-terminal
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA aldh6a1-002 (1) 826
    aldh6a1-003 (1) 764
    aldh6a1-201 (1)    Ensembl 2124
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aldh6a1 No data available
    MARKER RELATIONSHIPS
    aldh6a1 Contained in: [BAC] CH73-213B8 (1)
    [Fosmid] ZFOS-810H6
    aldh6a1 Encodes: [EST] cb850 (1) (order this), fb03a04
    [cDNA] MGC:92082 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002374 (1) 2129 bp
    Genomic GenBank:CU694272 (1) 38971 bp
    Select Tool
    Polypeptide UniProtKB:Q6DHT4 (1) 525 aa
    Sequence Information (all 14)
    ORTHOLOGY for aldh6a1 ( Chr: 17 )
    CITATIONS (24)