Gene

aldh6a1

ID
ZDB-GENE-030131-9192
Name
aldehyde dehydrogenase 6 family, member A1
Symbol
aldh6a1 Nomenclature History
Previous Names
  • cb850 (1)
  • mitochondrial acylating methylmalonate-semialdehyde dehydrogenase
  • wu:fb03a04
  • zgc:92082
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have malonate-semialdehyde dehydrogenase (acetylating) activity and methylmalonate-semialdehyde dehydrogenase (acylating) activity. Predicted to be involved in thymine catabolic process and valine catabolic process. Predicted to localize to mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; midbrain; musculature system; and ventricular zone. Orthologous to human ALDH6A1 (aldehyde dehydrogenase 6 family member A1).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from Thisse et al., 2001
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With aldh6a1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Methylmalonate semialdehyde dehydrogenase deficiency 614105
Associated With aldh6a1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR016160 Aldehyde dehydrogenase, cysteine active site
Domain IPR015590 Aldehyde dehydrogenase domain
Family IPR010061 Methylmalonate-semialdehyde dehydrogenase
Homologous_superfamily IPR016161 Aldehyde/histidinol dehydrogenase
Homologous_superfamily IPR016162 Aldehyde dehydrogenase, N-terminal
Homologous_superfamily IPR016163 Aldehyde dehydrogenase, C-terminal
Domain Details Per Protein
Protein Length Aldehyde dehydrogenase, C-terminal Aldehyde dehydrogenase, cysteine active site Aldehyde dehydrogenase domain Aldehyde dehydrogenase, N-terminal Aldehyde/histidinol dehydrogenase Methylmalonate-semialdehyde dehydrogenase
UniProtKB:Q6DHT4 525
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations