ZFIN ID: ZDB-GENE-030131-9174
Gene Name: glycyl-tRNA synthetase 1
Gene Symbol: gars1    Nomenclature History

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Previous Names: gars, mrn (1), metronome (1), si:dkey-276i5.1 (1), wu:fb02f03 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have glycine-tRNA ligase activity. Involved in translation. Predicted to localize to mitochondrion. Is expressed in several structures, including anterior neural keel; blood island; central nervous system; heart; and segmental plate. Used to study Charcot-Marie-Tooth disease type 2. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and distal hereditary motor neuronopathy type 5A. Orthologous to human GARS1 (glycyl-tRNA synthetase 1).
Genome Resources: Alliance (1),  Gene:337230 (1),  Ensembl(GRCz11):ENSDARG00000059070 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
s266 Point Mutation Unknown Missense ENU
sa13782 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24482 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24483 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37871 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gars1
    1
    CRISPR2-gars1
    1
    CRISPR3-gars1
    1
    MO1-gars1 N/A 1
    MO2-gars1 N/A 1
    DISEASE ASSOCIATED WITH gars1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease type 2D Alliance Charcot-Marie-Tooth disease, type 2D 601472
    distal hereditary motor neuronopathy type 5A Alliance Neuronopathy, distal hereditary motor, type VA 600794
    DISEASE ASSOCIATED WITH gars1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Charcot-Marie-Tooth disease type 2 gars1s266/s266 standard conditions Malissovas et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process translation (more)
    Cellular Component cytoplasm (more)
    Molecular Function aminoacyl-tRNA ligase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gars-201 (1)    Ensembl 2622
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-gars polyclonal IgG Rabbit WB Abcam plc
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gars1 No data available
    MARKER RELATIONSHIPS
    gars1 Contained in: [BAC] DKEY-276I5 (1) (order this)
    gars1 Encodes: [EST] fb02f03, IMAGE:7144596 (1), IMAGE:7162501 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_017353962 (1)
    Genomic GenBank:BX571770 (1) 166454 nt
    Select Tool
    Polypeptide UniProtKB:Q4V9I4 (1) 764 aa
    Sequence Information (all 18)
    ORTHOLOGY for gars1 ( Chr: 24 )
    CITATIONS (28)