Gene

cpn1

ID

ZDB-GENE-030131-9116

Name

carboxypeptidase N, polypeptide 1

Symbol

cpn1 Nomenclature History

Previous Names

cb1037 (1)
fa99g08
wu:fa99g08 (1)

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have metallocarboxypeptidase activity. Involved in cellular response to estrogen stimulus; liver development; and sprouting angiogenesis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in carboxypeptidase N deficiency. Is expressed in several structures, including digestive system; mesoderm; nervous system; pectoral fin cartilage; and vasculature. Orthologous to human CPN1 (carboxypeptidase N subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb1037 (23 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Wu et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cpn1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
carboxypeptidase N deficiency	Alliance	Carboxypeptidase N deficiency	212070

Associated With cpn1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000834	Peptidase M14, carboxypeptidase A
Homologous_superfamily	IPR008969	Carboxypeptidase-like, regulatory domain superfamily

Domain Details Per Protein

Protein	Length	Carboxypeptidase-like, regulatory domain superfamily	Peptidase M14, carboxypeptidase A
UniProtKB:Q6NY94 InterPro	450

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cpn1-201 (1) Ensembl	Havana	1847 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cpn1-204 (1) Ensembl	Havana	1996 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cr352342.1-201 (1) Ensembl	Havana	531 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	cpn1-002 (1) Ensembl	Havana	643 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	cpn1-003 (1) Ensembl	Havana	768 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations