ZFIN ID: ZDB-GENE-030131-9116
Gene Name: carboxypeptidase N, polypeptide 1
Gene Symbol: cpn1    Nomenclature History

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Previous Names: cb1037 (1), fa99g08, wu:fa99g08 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have metallocarboxypeptidase activity. Involved in cellular response to estrogen stimulus; liver development; and sprouting angiogenesis. Predicted to localize to extracellular space. Is expressed in several structures, including digestive system; mesoderm; nervous system; pectoral fin cartilage; and vasculature. Human ortholog(s) of this gene implicated in carboxypeptidase N deficiency. Orthologous to human CPN1 (carboxypeptidase N subunit 1).
Genome Resources: Alliance (1),  Gene:337172 (1), 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011360Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11899 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cpn1 N/A 1
    MO2-cpn1 N/A 1
    MO3-cpn1 N/A 1
    MO4-cpn1 N/A 1
    DISEASE ASSOCIATED WITH cpn1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    carboxypeptidase N deficiency Alliance Carboxypeptidase N deficiency 212070
    DISEASE ASSOCIATED WITH cpn1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to estrogen stimulus (more)
    Cellular Component extracellular space (more)
    Molecular Function carboxypeptidase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cpn1-201 (1)    Ensembl 1847
    cpn1-204 (1)    Ensembl 1996
    cr352342.1-201 (1)    Ensembl 531
    ncRNA cpn1-002 (1)    Ensembl 643
    cpn1-003 (1)    Ensembl 768
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cpn1 No data available
    MARKER RELATIONSHIPS
    cpn1 Contained in: [BAC] CH211-134H7 (1)
    cpn1 Encodes: [EST] cb1037 (1) (order this), fa99g08
    [cDNA] MGC:77485 (1), MGC:174789 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212770 (1) 1786 nt
    Genomic GenBank:CR352342 (1) 186937 nt
    Select Tool
    Polypeptide UniProtKB:U3JB00 (1) 582 aa
    Sequence Information (all 19)
    ORTHOLOGY for cpn1 ( Chr: 12 )
    CITATIONS (29)