Gene

prkdc

ID

ZDB-GENE-030131-9008

Name

protein kinase, DNA-activated, catalytic subunit

Symbol

prkdc Nomenclature History

Previous Names

fa96e12
wu:fa96e12 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Involved in B cell differentiation; T cell receptor V(D)J recombination; and immunoglobulin heavy chain V-D-J recombination. Predicted to localize to nucleus. Used to study severe combined immunodeficiency. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in kidney and spleen. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7147291 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prkdc Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 26	Alliance	Immunodeficiency 26, with or without neurologic abnormalities	615966

Associated With prkdc Via Experimental Models

Human Disease	Fish	Conditions	Citations
severe combined immunodeficiency	prkdc^yu27/yu27 (AB)	standard conditions	Jung et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
Domain	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain	IPR003151	PIK-related kinase, FAT
Domain	IPR003152	FATC domain
Domain	IPR012582	DNA-dependent protein kinase catalytic subunit, CC3
Domain	IPR014009	PIK-related kinase
Domain	IPR037706	DNA-dependent protein kinase catalytic subunit, catalytic domain
Domain	IPR045581	DNA-dependent protein kinase catalytic subunit, CC5
Domain	IPR046803	DNA-dependent protein kinase catalytic subunit, CC1/2
Domain	IPR046804	DNA-PKcs, N-terminal
Family	IPR050517	DNA Damage Response and Repair Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

Domain Details Per Protein

Protein	Length	Armadillo-type fold	DNA Damage Response and Repair Kinase	DNA-dependent protein kinase catalytic subunit, catalytic domain	DNA-dependent protein kinase catalytic subunit, CC1/2	DNA-dependent protein kinase catalytic subunit, CC3	DNA-dependent protein kinase catalytic subunit, CC5	DNA-PKcs, N-terminal	FATC domain	Phosphatidylinositol 3-/4-kinase, catalytic domain	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Phosphatidylinositol 3/4-kinase, conserved site	PIK-related kinase	PIK-related kinase, FAT	Protein kinase-like domain superfamily
UniProtKB:E7F4J7 InterPro	4119

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	prkdc-201 (1) Ensembl	Ensembl		12,981 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-prkdc		prkdc		Mouse	IHC WB	Abmart	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations