Gene

prkdc

ID
ZDB-GENE-030131-9008
Name
protein kinase, DNA-activated, catalytic subunit
Symbol
prkdc Nomenclature History
Previous Names
  • fa96e12
  • wu:fa96e12 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in B cell differentiation; T cell receptor V(D)J recombination; and immunoglobulin heavy chain V-D-J recombination. Predicted to localize to nucleus. Is expressed in kidney and spleen. Used to study severe combined immunodeficiency. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prkdc Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 26 Alliance Immunodeficiency 26, with or without neurologic abnormalities 615966
Associated With prkdc Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
Domain IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain IPR003151 PIK-related kinase, FAT
Domain IPR003152 FATC domain
Domain IPR012582 NUC194
Domain IPR014009 PIK-related kinase
Domain IPR037706 DNA-dependent protein kinase catalytic subunit, catalytic domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Domain Details Per Protein
Protein Length Armadillo-type fold DNA-dependent protein kinase catalytic subunit, catalytic domain FATC domain NUC194 Phosphatidylinositol 3-/4-kinase, catalytic domain Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily Phosphatidylinositol 3/4-kinase, conserved site PIK-related kinase PIK-related kinase, FAT Protein kinase-like domain superfamily
UniProtKB:E7F4J7 4119
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-prkdc Mouse
  • IHC
  • WB
Abmart
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations