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ZIRC
ZFIN ID: ZDB-GENE-030131-9008
Gene Name: protein kinase, DNA-activated, catalytic subunit
Gene Symbol: prkdc
Sequence Ontology ID : SO:0000704

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Attributions

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Previous Names: fa96e12, wu:fa96e12 (1)

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(Including Attributions)
Location: Chr: 7 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have protein serine/threonine kinase activity. Involved in B cell differentiation; T cell receptor V(D)J recombination; and immunoglobulin heavy chain V-D-J recombination. Predicted to  ...
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7147291]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fb103 Small Deletion Unknown Frameshift, Premature Stop TALEN
sa903 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa978 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa7082 Point Mutation Unknown Splice Site ENU
    sa12418 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13311 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13548 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16262 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17162 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21045 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21046 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27016 Point Mutation Unknown Premature Stop ENU
    sa34147 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34148 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40976 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40977 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45288 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45289 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • yu27 Indel Exon 3 Frameshift TALEN
    Targeting reagents:
    DISEASE ASSOCIATED WITH prkdc HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Immunodeficiency 26, with or without neurologic abnormalities 615966
    DISEASE ASSOCIATED WITH prkdc VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    severe combined immunodeficiency prkdcyu27/yu27(AB) standard conditions Jung et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process B cell differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function ATP binding (more)
    GO Terms (all 19)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA prkdc-201 (1) 12981
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM prkdc No data available
    MARKER RELATIONSHIPS
    prkdcContained in: [BAC] CH211-198H5 (1) (order this), DKEY-86L18 (1) (order this)
    prkdcEncodes: [EST] fa96e12, IMAGE:7147291 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_009303401 (1)
    Genomic GenBank:CT574559 (1) 110868bp
    Select Tool
    Polypeptide UniProtKB:E7F4J7 (1) 4119aa
    Sequence Clusters UniGene:159456 (1)
    Sequence Information (all 14)
    ORTHOLOGY for prkdc (Chr: 7)
    CITATIONS (25)