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ZIRC
ZFIN ID: ZDB-GENE-030131-8942
Gene Name: checkpoint kinase 2
Gene Symbol: chek2
Sequence Ontology ID : SO:0000704

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Previous Names: chk2 (1), fa66f08, wu:fa66f08, zgc:55865

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(Including Attributions)
Location: Chr: 5 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have protein serine/threonine kinase activity; involved in cellular response to DNA damage stimulus; predicted to localize to the cytoplasm and nucleus; orthologous to human CHEK2  ...
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Segmentation:26+ somites (22.0h-24.0h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la024778Tg Transgenic Insertion Unknown Unknown DNA
sa20350 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33537 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH chek2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    breast cancer {Breast cancer, susceptibility to} 114480
    Li-Fraumeni syndrome Li-Fraumeni syndrome 609265
    osteosarcoma Osteosarcoma, somatic 259500
    prostate cancer {Prostate cancer, familial, susceptibility to} 176807
    {Breast and colorectal cancer, susceptibility to}
    DISEASE ASSOCIATED WITH chek2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to DNA damage stimulus (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 15)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA chek2-201 (1) 1816
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM chek2 No data available
    MARKER RELATIONSHIPS
    chek2Contained in: [BAC] CH211-207K7 (1) (order this)
    chek2Encodes: [EST] fa66f08
    [cDNA] MGC:55865 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200045 (1) 1802bp
    Genomic GenBank:CR854962 (1) 217242bp Blast at MegaBLAST
    Polypeptide UniProtKB:B0V1J5 (1) 503aa
    Sequence Clusters UniGene:76006 (1)
    Sequence Information (all 16)
    ORTHOLOGY for chek2 (Chr: 5)
    CITATIONS (29)