ZFIN ID: ZDB-GENE-030131-8820
Gene Name: toll interacting protein
Gene Symbol: tollip    Nomenclature History

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Previous Names: fk22a02, im:7145391, wu:fk22a02, zgc:76985

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have ubiquitin binding activity and ubiquitin conjugating enzyme binding activity. Involved in negative regulation of Wnt signaling pathway. Predicted to localize to cytoplasm. Orthologous to human TOLLIP (toll interacting protein).
Genome Resources: Alliance (1),  Gene:336876 (1),  Ensembl(GRCz11):ENSDARG00000098486 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7145391]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa968 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa7111 Point Mutation Unknown Premature Stop ENU
    sa12341 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21153 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tollip N/A 1
    MO2-tollip N/A 1
    MO3-tollip N/A 1
    DISEASE ASSOCIATED WITH tollip HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tollip VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of Wnt signaling pathway (more)
    Cellular Component cytoplasm (more)
    Molecular Function ubiquitin binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tollip-201 (1)    Ensembl 918
    tollip-202 (1)    Ensembl 1305
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tollip No data available
    MARKER RELATIONSHIPS
    tollip Contained in: [BAC] CH73-343M12 (1)
    tollip Encodes: [EST] fk22a02, IMAGE:7145391 (1)
    [cDNA] MGC:56229 (1), MGC:76985 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_207061 (1) 1340 nt
    Genomic GenBank:CU463038 (1) 109814 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IZ33 (1) 276 aa
    Sequence Information (all 23)
    ORTHOLOGY for tollip ( Chr: 7 )
    CITATIONS (26)