ZFIN ID: ZDB-GENE-030131-8625
Gene Name: tubulin, beta 4B class IVb
Gene Symbol: tubb4b    Nomenclature History

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Previous Names: tubb2 (1), tubb2c, fa91f09, fb16e09, wu:fa91f09 (1), wu:fa92d05, wu:fb16e09, wu:fb97a11

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have GTP binding activity. Involved in cilium assembly. Predicted to localize to the cytoplasm and microtubule. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 6 and torsion dystonia 4. Is expressed in brain. Orthologous to several human genes including TUBB4B (tubulin beta 4B class IVb).
Genome Resources: Alliance (1),  Gene:336681 (1),  Ensembl(GRCz11):ENSDARG00000002344 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:65803]
  1 figure (1 image) from Thisse et al., 2004 [MGC:77620]
  1 figure (1 image) from Rauch et al., 2003 [fb16e09]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-tubb4b N/A 1
MO2-tubb4b N/A 1
DISEASE ASSOCIATED WITH tubb4b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Leber congenital amaurosis with early-onset deafness 617879
DISEASE ASSOCIATED WITH tubb4b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cilium assembly (more)
Cellular Component cytoplasm (more)
Molecular Function GTPase activity (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Binding_site IPR013838 Beta tubulin, autoregulation binding site
Conserved_site IPR017975 Tubulin, conserved site
Domain IPR003008 Tubulin/FtsZ, GTPase domain
Domain IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
Family IPR000217 Tubulin
Family IPR002453 Beta tubulin
Homologous_superfamily IPR008280 Tubulin/FtsZ, C-terminal
Homologous_superfamily IPR023123 Tubulin, C-terminal
Homologous_superfamily IPR036525 Tubulin/FtsZ, GTPase domain superfamily
Homologous_superfamily IPR037103 Tubulin/FtsZ, C-terminal domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tubb4b-001 (1) 1615
tubb4b-202 (1)    Ensembl 559
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tubb4b No data available
MARKER RELATIONSHIPS
tubb4b Contained in: [BAC] CH73-305J1 (1), DKEY-227L13 (1) (order this)
tubb4b Encodes: [EST] fa91f09 (1), fa92d05, fb16e09 (order this), fb97a11
[cDNA] MGC:65803 (1), MGC:77620 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_198809 (1) 1573 nt
Genomic GenBank:BX511303 190512 nt
Select Tool
Polypeptide UniProtKB:Q6P5M9 (1) 445 aa
Sequence Information (all 28)
ORTHOLOGY for tubb4b ( Chr: 14 )
CITATIONS (35)