ZFIN ID: ZDB-GENE-030131-8415
Gene Name: collagen, type I, alpha 2
Gene Symbol: col1a2
Previous Names: alpha2(I) (1), hm:zehn2357, wu:fa98d05 (1), wu:fa99g10 (1), wu:fb04c08, wu:fb11d06, zehn2357
Location: Chr: 19   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 25 figures from 15 publications
Directly Submitted Expression Data: 6 figures (20 images) from Thisse et al., 2004 [IMAGE:7145608]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
  branchiostegal ray 3, ceratobranchial 5 tooth osteoblast, ceratohyal cartilage perichondrium, cleithrum (all 26) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 1 genotype
Alleles: la013496Tg, sa1763, sa17981
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Ehlers-Danlos syndrome, cardiac valvular form 225320
Ehlers-Danlos syndrome, type VIIB 130060
Osteogenesis imperfecta, type II 166210
Osteogenesis imperfecta, type III 259420
Osteogenesis imperfecta, type IV 166220
{Osteoporosis, postmenopausal} 166710
GENE ONTOLOGY
Ontology GO Term
Biological Process response to mechanical stimulus (more)
Cellular Component collagen trimer (more)
Molecular Function extracellular matrix structural constituent (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000885 (1)
  • InterPro:IPR008160 (1)
  • PROSITE:PS51461 (1)
  • Pfam:PF01391 (1)
  • Pfam:PF01410 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA col1a2-001 (1) 5750
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM col1a2 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    col1a2 Contained in: [BAC] DKEY-104M9 (1)
    col1a2 Encodes: [EST] fa98d05 (1), fa99g10 (1), fb04c08, fb11d06, IMAGE:7145608 (1) (order this), zehn2357
    [cDNA] MGC:85701 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_182968 (1) 5182 bp
    Genomic GenBank:BX640469 (1) 83435 bp
    Select Tool
    Polypeptide UniProtKB:E9QCG6 (1) 1352 aa
    Sequence Clusters UniGene:75575 (1)
    Sequence Information (all 28)
    OTHER col1a2 GENE PAGES
  • Gene:336471 (1)
  • VEGA:OTTDARG00000015600 (1)
  • Ensembl(Zv9):ENSDARG00000020007 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA NT CL
    Zebrafish col1a2 19  
    Human COL1A2 7 (7q22.1)
  • OMIM:120160
  • Gene:1278
  • Mouse Col1a2 6 ( 1.81 cM)
  • MGI:88468
  • Gene:12843
  • Orthology Details
    CITATIONS (56)