ZFIN ID: ZDB-GENE-030131-8415
Gene Name: collagen, type I, alpha 2
Gene Symbol: col1a2
Previous Names: alpha2(I) (1), hm:zehn2357, wu:fa98d05 (1), wu:fa99g10 (1), wu:fb04c08, wu:fb11d06, zehn2357
Location: Chr: 19   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 27 figures from 17 publications
Directly Submitted Expression Data: 6 figures (20 images) from Thisse et al., 2004 [IMAGE:7145608]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
  branchiostegal ray 3, ceratobranchial 5 tooth osteoblast, ceratohyal cartilage perichondrium, cleithrum (all 27) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: col1a2sa1763/sa1763(Tupfel long fin)

Allele Type Mutagen Suppliers
la013496Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1763 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17981 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH col1a2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    osteogenesis imperfecta Osteogenesis imperfecta, type II 166210
    Osteogenesis imperfecta, type III 259420
    Osteogenesis imperfecta, type IV 166220
    osteoporosis {Osteoporosis, postmenopausal} 166710
    Ehlers-Danlos syndrome, cardiac valvular form 225320
    Ehlers-Danlos syndrome, type VIIB 130060
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to mechanical stimulus (more)
    Cellular Component collagen trimer (more)
    Molecular Function extracellular matrix structural constituent (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000885 (1)
  • InterPro:IPR008160 (1)
  • PROSITE:PS51461 (1)
  • Pfam:PF01391 (1)
  • Pfam:PF01410 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA col1a2-001 (1) 5750
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM col1a2 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    col1a2 Contained in: [BAC] DKEY-104M9 (1) (order this)
    col1a2 Encodes: [EST] fa98d05 (1), fa99g10 (1), fb04c08, fb11d06, IMAGE:7145608 (1) (order this), zehn2357
    [cDNA] MGC:85701 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_182968 (1) 5182 bp
    Genomic GenBank:BX640469 (1) 83435 bp
    Select Tool
    Polypeptide UniProtKB:E9QCG6 (1) 1352 aa
    Sequence Clusters UniGene:75575 (1)
    Sequence Information (all 28)
    OTHER col1a2 GENE PAGES
  • Gene:336471 (1)
  • VEGA:OTTDARG00000015600 (1)
  • Ensembl(Zv9):ENSDARG00000020007 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA NT CL
    Zebrafish col1a2 19  
    Human COL1A2 7 (7q22.1)
  • OMIM:120160
  • Gene:1278
  • Mouse Col1a2 6 ( 1.81 cM)
  • MGI:88468
  • Gene:12843
  • Orthology Details
    CITATIONS (58)