Gene

gnb1a

ID
ZDB-GENE-030131-823
Name
guanine nucleotide binding protein (G protein), beta polypeptide 1a
Symbol
gnb1a Nomenclature History
Previous Names
  • gnb1 (1)
  • wu:fb50b09
  • wu:fj94h04
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Involved in positive regulation of neutrophil migration and posterior lateral line neuromast primordium migration. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia and autosomal dominant non-syndromic intellectual disability 42. Is expressed in several structures, including blastomere; brain; epidermis; fin; and sensory system. Orthologous to human GNB1 (G protein subunit beta 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
26 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Xu et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gnb1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute lymphoblastic leukemia Alliance Leukemia, acute lymphoblastic, somatic 613065
autosomal dominant non-syndromic intellectual disability 42 Alliance Intellectual developmental disorder, autosomal dominant 42 616973
myelodysplastic syndrome Alliance Myelodysplastic syndrome, somatic 614286
Associated With gnb1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019775 WD40 repeat, conserved site
Domain IPR001632 G-protein, beta subunit
Domain IPR017986 WD40-repeat-containing domain
Family IPR016346 Guanine nucleotide-binding protein, beta subunit
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Repeat IPR001680 WD40 repeat
Repeat IPR020472 G-protein beta WD-40 repeat
Domain Details Per Protein
Protein Length G-protein, beta subunit G-protein beta WD-40 repeat Guanine nucleotide-binding protein, beta subunit WD40 repeat WD40 repeat, conserved site WD40-repeat-containing domain WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q6PH57 340
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-gnb1a polyclonal IgG Rabbit
  • IHC
GeneTex
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations