ZFIN ID: ZDB-GENE-030131-823
Gene Name: guanine nucleotide binding protein (G protein), beta polypeptide 1a
Gene Symbol: gnb1a    Nomenclature History

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Previous Names: gnb1 (1), wu:fb50b09, wu:fj94h04

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have G-protein gamma-subunit binding activity. Involved in positive regulation of neutrophil migration and posterior lateral line neuromast primordium migration. Predicted to localize to cytoplasm and heterotrimeric G-protein complex. Is expressed in several structures, including blastomere; brain; epidermis; fin; and sensory system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia and autosomal dominant non-syndromic intellectual disability 42. Orthologous to human GNB1 (G protein subunit beta 1).
Genome Resources: Alliance (1),  Gene:322104 (1),  Ensembl(GRCz11):ENSDARG00000090454 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-gnb1a N/A 4
MO2-gnb1a N/A 3
DISEASE ASSOCIATED WITH gnb1a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute lymphoblastic leukemia Alliance Leukemia, acute lymphoblastic, somatic 613065
autosomal dominant non-syndromic intellectual disability 42 Alliance Mental retardation, autosomal dominant 42 616973
DISEASE ASSOCIATED WITH gnb1a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of neutrophil migration (more)
Cellular Component cytoplasm (more)
Molecular Function G-protein gamma-subunit binding (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-gnb1a polyclonal IgG Rabbit IHC GeneTex
3
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM gnb1a No data available
MARKER RELATIONSHIPS
gnb1a Encodes: [EST] fb50b09, fc59a01 (1) (order this), fj94h04 (1)
[cDNA] MGC:65927 (1), MGC:85666 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_212609 (1) 3230 nt
Genomic GenBank:CABZ01070131 (1) 22558 nt
Polypeptide UniProtKB:Q6PH57 (1) 340 aa
Sequence Information (all 25)
ORTHOLOGY for gnb1a ( Chr: 8 )
CITATIONS (38)