Gene

pclob

ID

ZDB-GENE-030131-8100

Name

piccolo presynaptic cytomatrix protein b

Symbol

pclob Nomenclature History

Previous Names

si:ch73-339d2.2
si:dkey-266j7.1 (1)
wu:fj52d10 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity. Predicted to be involved in synapse assembly. Predicted to localize to membrane and presynaptic active zone. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Is expressed in brain; cerebellum; hindbrain; and torus longitudinalis. Orthologous to human PCLO (piccolo presynaptic cytomatrix protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Nonet, 2012

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pclob Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
pontocerebellar hypoplasia type 3	Alliance	?Pontocerebellar hypoplasia, type 3	608027

Associated With pclob Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000008	C2 domain
Domain	IPR001478	PDZ domain
Domain	IPR001565	Synaptotagmin
Domain	IPR008899	Zinc finger, piccolo-type
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	C2 domain	C2 domain superfamily	PDZ domain	PDZ superfamily	Synaptotagmin	Zinc finger, FYVE/PHD-type	Zinc finger, piccolo-type	Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A8M6YW34 InterPro	9346
UniProtKB:A0A8M9PFP9 InterPro	9337
UniProtKB:A0A0R4IGI4 InterPro	9346
UniProtKB:A0A8M3AJG6 InterPro	9355
UniProtKB:A0A8M6YTM4 InterPro	7373

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pclob-201 (1) Ensembl	Havana	30840 nt	Select Tool MegaBLAST Ensembl
ncRNA	ottdart00000062336 (1) Ensembl	Havana	496 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations