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ZIRC
ZFIN ID: ZDB-GENE-030131-7871
Gene Name: CD59 molecule (CD59 blood group)
Gene Symbol: cd59    Nomenclature History

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Previous Names: fj38b04, lndc1, ly6/neurotoxin like, wu:fj38b04

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Exhibits lipopolysaccharide binding activity and lipoteichoic acid binding activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Localizes to the membrane. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer. Is expressed in several structures, including blood; central nervous system; hypochord; ovary; and unfertilized egg. Orthologous to human CD59 (CD59 molecule (CD59 blood group)).
Genome Resources: Alliance (1),  Gene:567192 (1),  Ensembl(GRCz11):ENSDARG00000090615 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cd59 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Hemolytic anemia, CD59-mediated, with or without immune-mediated polyneuropathy 612300
DISEASE ASSOCIATED WITH cd59 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process defense response to Gram-negative bacterium (more)
Cellular Component membrane (more)
Molecular Function lipopolysaccharide binding (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR016054 (1)
  • Pfam:PF00021 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cd59-201 (1)    Ensembl 1133
    cd59-202 (1)    Ensembl 628
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cd59 polyclonal Rabbit IHC, WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cd59 No data available
    MARKER RELATIONSHIPS
    cd59 Contained in: [BAC] DKEY-150L7 (1) (order this)
    cd59 Encodes: [EST] fj38b04
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001326385 (1)
    Genomic GenBank:BX957297 (1) 79980 bp
    Select Tool
    Polypeptide UniProtKB:E7F2M5 (1) 118 aa
    Sequence Clusters UniGene:81026 (1)
    Sequence Information (all 16)
    ORTHOLOGY for cd59 ( Chr: 7 )
    CITATIONS (14)