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ZIRC
ZFIN ID: ZDB-GENE-030131-7393
Gene Name: granulin b
Gene Symbol: grnb
Sequence Ontology ID : SO:0000704

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Previous Names: fj14b08, wu:fj14b08, zfPGRN-B (1), zgc:111858

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(Including Attributions)
Location: Chr: 24 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Involved in axon extension. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); and neuronal ceroid lipofuscinosis 11. Orthologous to human GRN  ...
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mde357a Small Deletion Exon 5 Unknown ZINC_FINGER_NUCLEASE
  • European Zebrafish Resource Center (EZRC) (order this)
  • mde360 Indel Exon 5 Unknown ZINC_FINGER_NUCLEASE
  • European Zebrafish Resource Center (EZRC) (order this)
  • mde369 Insertion Exon 5 Unknown ZINC_FINGER_NUCLEASE
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa30129 Point Mutation Unknown Premature Stop ENU
    sa37944 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: Fig. 1 from Laird et al., 2010
    Observed in:
    DISEASE ASSOCIATED WITH grnb HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Grn-related frontotemporal lobar degeneration with Tdp43 inclusions Aphasia, primary progressive 607485
    Frontotemporal lobar degeneration with ubiquitin-positive inclusions 607485
    neuronal ceroid lipofuscinosis 11 Ceroid lipofuscinosis, neuronal, 11 614706
    DISEASE ASSOCIATED WITH grnb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon extension (more)
    GO Terms (all 1)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA grnb-201 (1) 2872
    grnb-202 (1) 494
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM grnb No data available
    MARKER RELATIONSHIPS
    grnbContained in: [BAC] CH211-40K21 (1) (order this), CH211-253B1 (1) (order this)
    grnbEncodes: [EST] fj14b08
    [cDNA] MGC:111858 (1) (order this), MGC:191140 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212738 (1) 2820bp
    Genomic GenBank:FP089511 (1) 158292bp
    Select Tool
    Polypeptide UniProtKB:F1R6I2 (1) 729aa
    Sequence Clusters UniGene:80791 (1)
    Sequence Information (all 24)
    ORTHOLOGY for grnb (Chr: 24)
    CITATIONS (27)