Gene

socs3a

ID
ZDB-GENE-030131-7349
Name
suppressor of cytokine signaling 3a
Symbol
socs3a Nomenclature History
Previous Names
  • socs3
  • fj09e12
  • wu:fj09e12
  • zgc:56537 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Acts upstream of or within several processes, including hepatocyte differentiation; negative regulation of axon regeneration; and sensory system development. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in eye; lateral line; and liver. Human ortholog(s) of this gene implicated in atopic dermatitis 4. Orthologous to human SOCS3 (suppressor of cytokine signaling 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With socs3a Human Ortholog
No data available
Associated With socs3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000980 SH2 domain
Domain IPR001496 SOCS box domain
Domain IPR035863 SOCS3, SH2 domain
Family IPR028414 Suppressor of cytokine signalling 3
Homologous_superfamily IPR036036 SOCS box-like domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length SH2 domain SH2 domain superfamily SOCS3, SH2 domain SOCS box domain SOCS box-like domain superfamily Suppressor of cytokine signalling 3
UniProtKB:L0N8K9 207
UniProtKB:Q1KZH6 207
UniProtKB:Q7ZUC6 207
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-socs3a polyclonal Rabbit
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations