Gene

itgb4

ID
ZDB-GENE-030131-7209
Name
integrin, beta 4
Symbol
itgb4 Nomenclature History
Previous Names
  • fl03d06
  • wu:fb72e01
  • wu:fc27g01
  • wu:fl03d06
  • zgc:136313 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to localize to cell surface; focal adhesion; and integrin complex. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex localized type; junctional epidermolysis bullosa non-Herlitz type; and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGB4 (integrin subunit beta 4).
Genome Resources
Note
None
Expression
All Expression Data
from Li et al., 2011
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With itgb4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
epidermolysis bullosa simplex localized type Alliance Epidermolysis bullosa of hands and feet 131800
junctional epidermolysis bullosa non-Herlitz type Alliance Epidermolysis bullosa, junctional, non-Herlitz type 226650
junctional epidermolysis bullosa with pyloric atresia Alliance Epidermolysis bullosa, junctional, with pyloric atresia 226730
Associated With itgb4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Domain IPR002369 Integrin beta subunit, VWA domain
Domain IPR003644 Na-Ca exchanger/integrin-beta4
Domain IPR003961 Fibronectin type III
Domain IPR012896 Integrin beta subunit, tail
Domain IPR016201 PSI domain
Domain IPR033760 Integrin beta N-terminal
Domain IPR040622 Integrin beta, epidermal growth factor-like domain 1
Family IPR012013 Integrin beta-4 subunit
Family IPR015812 Integrin beta subunit
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036349 Integrin beta tail domain superfamily
Homologous_superfamily IPR036465 von Willebrand factor A-like domain superfamily
Homologous_superfamily IPR038081 CalX-like domain superfamily
Domain Details Per Protein
Protein Length CalX-like domain superfamily EGF-like domain Fibronectin type III Fibronectin type III superfamily Immunoglobulin-like fold Integrin beta-4 subunit Integrin beta, epidermal growth factor-like domain 1 Integrin beta N-terminal Integrin beta subunit Integrin beta subunit, tail Integrin beta subunit, VWA domain Integrin beta tail domain superfamily Na-Ca exchanger/integrin-beta4 PSI domain von Willebrand factor A-like domain superfamily
UniProtKB:F1RA51 1893
UniProtKB:Q4U0S1 1893
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations